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Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.
- K. Griendling, C. Minieri, J. Ollerenshaw, R. Alexander
- Chemistry, MedicineCirculation research
- 1 June 1994
The ability of Ang II to stimulate superoxide anion formation is examined and the identity of the oxidases responsible for its production is investigated to suggest that Ang II specifically activates enzyme systems that promote superoxide generation and raise the possibility that these pathways function as second messengers for long-term responses, such as hypertrophy or hyperplasia.
Arachidonic acid metabolites mediate angiotensin II-induced NADH/NADPH oxidase activity and hypertrophy in vascular smooth muscle cells.
- A. Zafari, M. Ushio-Fukai, C. Minieri, M. Akers, B. Lassègue, K. Griendling
- Chemistry, MedicineAntioxidants & redox signaling
Exogenous noncyclooxygenase arachidonic acid metabolites mediate angiotensin II-stimulated protein synthesis in cultured VSMC by activating the NADH/NADPH oxidase, providing mechanistic evidence for redox control of VSMC hypertrophy.
Prolonged exposure to agonist results in a reduction in the levels of the Gq/G11 alpha subunits in cultured vascular smooth muscle cells.
- H. Kai, T. Fukui, B. Lassègue, A. Shah, C. Minieri, K. Griendling
- Chemistry, MedicineMolecular pharmacology
The present study raises the possibility that agonist-induced G alpha q/G alpha 11 down-regulation participates in the mechanism of long term desensitization of the G alphaq/Galpha 11-mediated signaling system in VSMC.
vascular smooth muscle cells Angiotensin II stimulates NADH and NADPH oxidase activity in cultured
The signaling pathways involved in the long-term metabolic effects of angiotensin II (Ang II) in vascular smooth muscle cells are incompletely understood but include the generation of molecules…
Regulation of neural enhancer activity by Ascl1 and Sox factors
- C. Minieri
- 28 March 2014
A novel transcriptional regulatory network in the regulation of neuronal differentiation where Ascl1 and SoxC factors synergistically activate neuronal enhancers, and Sox2 counteracts AsCl1 in this activation.
Angiotensin II Stimulates NADH andNADPH Oxidase Activity inCultured Vascular SmoothMuscleCells
Thesignaling pathways involved inthelong-term metabolic effects ofangiotensin II (AngII)invascular smooth musclecells are incompletely understood butinclude the generation ofmolecules likely toaffect…