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BID: a novel BH3 domain-only death agonist.
TLDR
This work used interactive cloning to identify Bid, which encodes a novel death agonist that heterodimerizes with either agonists (BAX) or antagonists (BCL-2), and favors a model in which BID represents a death ligand for the membrane-bound receptor BAX.
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
TLDR
It is demonstrated that Bcl-2 is an integral inner mitochondrial membrane protein of relative molecular mass 25,000 (25k) being localized to mitochondria and interfering with programmed cell death independent of promoting cell division.
Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death*
TLDR
While BID appears to be required for the release of cytochrome c in the TNF death pathway, the release is likely not required for cell death, as other aspects of mitochondrial dysfunction still transpired and cells died nonetheless.
Porcine intervertebral disc repair using allogeneic juvenile articular chondrocytes or mesenchymal stem cells.
TLDR
The premise that committed chondrocytes are more appropriate for use in disc repair, as they are uniquely suited for survival in the ischemic disc microenvironment, is supported.
The Potential of Human Allogeneic Juvenile Chondrocytes for Restoration of Articular Cartilage
TLDR
Juile human chondrocytes have greater potential to restore articular cartilage than adult cells, and may be transplanted without the fear of rejection, suggesting a new allogeneic approach to restoring articularcartilage in older individuals.
Isolation and sequence analysis of a barley alpha-amylase cDNA clone.
TLDR
It is inferred that there must be at least two populations of alpha-amylase mRNA molecules derived from separate structural genes differently influenced by gibberellic acid in aleurone cells.
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