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Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
It is concluded that the contribution of CB1-type receptors expressed on the peripheral terminals of nociceptors to cannabinoid-induced analgesia is paramount, which should enable the development of peripherally acting CB1 analgesic agonists without any central side effects.
The role of stroma in pancreatic cancer: diagnostic and therapeutic implications
- M. Erkan, S. Hausmann, H. Friess
- Medicine, BiologyNature Reviews Gastroenterology &Hepatology
- 1 August 2012
Targeting the tumour stroma, in combination with chemotherapy, is a promising new option for the treatment of PDAC.
Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer.
StellaTUM: current consensus and discussion on pancreatic stellate cell research
Members of the Pancreatic Star Alliance discuss and consolidate current knowledge to outline and delineate areas of consensus or otherwise (eg, with regard to methodological approaches) and, more importantly, to identify essential directions for future research.
The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma.
Hematopoietic colony–stimulating factors mediate tumor-nerve interactions and bone cancer pain
Results show that G- CSF and GM-CSF are important in tumor-nerve interactions and suggest that their receptors on primary afferent nerve fibers constitute potential therapeutic targets in cancer pain.
Locally Advanced Pancreatic Cancer: Neoadjuvant Therapy With Folfirinox Results in Resectability in 60% of the Patients
Folfirinox seems to be the most effective protocol resulting in a significantly better secondary resection rate and overall survival than other treatments and should be considered in all patients fit for this regimen and consecutive surgical exploration.
Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma.
Although PSCs are the dominant producers of VEGF and increase endothelial cell growth in vitro, in the peritumoral stroma, they contribute to the fibrotic/hypoxic milieu through abnormal extracellular matrix deposition and by amplifying endostatin production of cancer cells.
Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer
A novel lncRNA, sncRNA and mRNA signature of PDAC is reported, which allows for assigning potential functions to differentially regulated RNAs.
Cannabinoids in pancreatic cancer: Correlation with survival and pain
Evaluation of immunoreactivity for cannabinoid‐1 and cannabinoid‐2 receptors as well as for the endocannabinoid metabolizing enzymes fatty acid amide hydrolase (FAAH) and monoacyl glycerol lipase (MGLL) revealed that these remained unchanged in PDAC compared to the normal pancreas.