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10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer.
BACKGROUND The comparative effectiveness of treatments for prostate cancer that is detected by prostate-specific antigen (PSA) testing remains uncertain. METHODS We compared active monitoring,Expand
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Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis
Objective To systematically review the literature and, where appropriate, meta-analyse studies investigating subsequent antibiotic resistance in individuals prescribed antibiotics in primary care.Expand
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Assessing the environmental fate of chemicals of emerging concern: a case study of the polybrominated diphenyl ethers.
It is suggested that assessments of chemicals of emerging concern can be rationally structured around a multistage process in which fate and risk are evaluated with increasing accuracy as new dataExpand
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Hospital Presenting Self-Harm and Risk of Fatal and Non-Fatal Repetition: Systematic Review and Meta-Analysis
Background Non-fatal self-harm is one of the most frequent reasons for emergency hospital admission and the strongest risk factor for subsequent suicide. Repeat self-harm and suicide are key clinicalExpand
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Prostate-cancer mortality in the USA and UK in 1975-2004: an ecological study.
BACKGROUND There is no conclusive evidence that screening based on serum prostate-specific antigen (PSA) tests decreases prostate-cancer mortality. Since its introduction in the USA around 1990,Expand
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Gonadal differentiation in frogs exposed to estrogenic and antiestrogenic compounds.
Exposure of amphibians to endocrine disrupting compounds (EDCs) may alter differentiation of gonads, especially when exposures begin during early life stages. Gonadal differentiation was observed inExpand
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Chronic, low concentration exposure to pharmaceuticals impacts multiple organ systems in zebrafish.
Pharmaceuticals are found in both receiving and drinking water due to their persistent release in waste-water effluents, raising concerns for environmental and human health. Chronic, aqueous exposureExpand
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Chronic effects of exposure to a pharmaceutical mixture and municipal wastewater in zebrafish.
Pharmaceuticals and personal care products (PPCPs) are discharged in municipal wastewater. Effects in aquatic organisms exposed to individual pharmaceuticals in the laboratory have raised concernsExpand
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Sleep duration and mortality: The effect of short or long sleep duration on cardiovascular and all-cause mortality in working men and women.
BACKGROUND There is evidence to suggest that insufficient sleep may have an adverse effect on physical and psychological health. Previous studies have reported that when adjusting for major riskExpand
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Psychological stress and cardiovascular disease: empirical demonstration of bias in a prospective observational study of Scottish men
Abstract Objectives: To examine the association between self perceived psychological stress and cardiovascular disease in a population where stress was not associated with social disadvantage.Expand
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