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Identification of a gain-of-function mutation of the prolactin receptor in women with benign breast tumors
TLDR
Hallmarks of constitutive activity were all reversed by a specific PrlR antagonist, which opens potential therapeutic approaches for MFA, or any other disease that could be associated with this mutation in future. Expand
Hormonal regulation of the androgen receptor expression in human prostatic cells in culture
TLDR
It is demonstrated that prostate epithelial cells and fibroblasts have retained in culture, an hormonal sensitivity correlated with the presence of specific receptors and can serve as a model for the study of hormone action in this tissue in normal or pathological conditions. Expand
Predominant expression of 5 alpha-reductase type 1 in pubic skin from normal subjects and hirsute patients.
Dihydrotestosterone (DHT), the 5 alpha-reduced metabolite of testosterone, is the active molecule triggering androgen action, and 5 alpha-reductase (5 alpha-R), the enzyme converting testosterone toExpand
A point mutation in the second zinc finger of the DNA-binding domain of the androgen receptor gene causes complete androgen insensitivity in two siblings with receptor-positive androgen resistance.
TLDR
The mutation renders the AR nonfunctional and can, therefore, be held responsible for the clinical features in these patients, highlighting the importance of Arginine-614 in the second zinc finger of the DNA-binding domain of the AR in the protein-DNA interaction. Expand
Pharmacological and molecular evidence for the expression of the two steroid 5α‐reductase isozymes in normal and hyperplastic human prostatic cells in culture
Whereas the embryological development of the human prostate is clearly dependent on steroid 5α‐reductase (5α‐R) type 2 expression, the respective expression of the two known isoforms (types 1 and 2)Expand