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Early indicators of exposure to biological threat agents using host gene profiles in peripheral blood mononuclear cells
TLDR
Host gene expression patterns have the potential to serve as diagnostic markers or predict the course of impending illness and may lead to new stage-appropriate therapeutic strategies to ameliorate the devastating effects of exposure to biothreat agents.
Anti-malarial drug development using models of enzyme structure.
TLDR
A new class of anti-malarial chemotherapeutics has resulted from a computational search that was based on a model of the target protease, and these compounds approach the activity of chloroquine, but have a distinct mechanism of action.
Cholera toxin induced gene expression alterations.
TLDR
The down regulation of Th1 markers and upregulation of Th2 markers by CT are consistent with the CT induction of Th3 cells and the CT induced responses correlated with those induced by CT subunits.
Induction of immunomodulator transcriptional responses by cholera toxin.
TLDR
The results suggest that immunomodulatory genes were among the genes that were affected the most by CT, and induction of these genes may contribute to the CT adjuvanticity.
Cholera toxin induced novel genes in human lymphocytes and monocytes.
TLDR
The transcriptional responses of cultured human lymphocytes and monocytes in response to CT were analyzed using differential display-PCR and 14 novel genes with previously unknown functions were found to be CT induced.
Alterations in Gene Expression Show Unique Patterns in Response to Toxic Agents
TLDR
Preliminary data using staphylococcal enterotoxin B as a prototype and 15 genes that were altered using the powerful technique of differential display suggest the potential usefulness of establishing a library of gene expression alterations in response to a battery of threat toxic agents.
Transcriptional response signature of human lymphoid cells to staphylococcal enterotoxin B
TLDR
Evidence is provided that vastly diverse global gene analysis techniques used in unison can not only effectively identify pathogen-specific genomic markers and provide a solid foundation to mechanistic insights but also explain some of the toxin-related symptoms through gene functions.
Effect of 5‐lipoxygenase inhibitor MK591 on early molecular and signaling events induced by staphylococcal enterotoxin B in human peripheral blood mononuclear cells
TLDR
This study revealed the activation of multiple divergent intracellular pathways within minutes of SEB induction including components that interconnect investigated pathways and the significance of pathway interconnectors such as 5‐LO as well as inhibiting such inter‐connectors in SEB induced human PBMCs.
Genetic variations in peripheral blood mononuclear cells in piglets used as an animal model for staphylococcal enterotoxin exposures.
TLDR
This study facilitates the characterization of gene expression base line needed for meaningful interpretation of microarray data to evaluate the normal physiological variation in gene expression in vivo in piglets.
Identification of Changes in Gene Expression Induced by Toxic Agents: Implications for Therapy and Rapid Diagnosis
TLDR
The degree of individual exposure is characterized in order to assist health personnel to rapidly differentiate those who will become seriously ill from "the worried well" individuals and reveal new therapeutic targets that can be initiated even in late- stage illness caused by biological threat agents.
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