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The free hormone hypothesis: a physiologically based mathematical model.
- C. Mendel
- Biology, MedicineEndocrine reviews
- 1 August 1989
It is shown that whether or not this hypothesis is likely to be valid for any given hormone will depend largely on which step in the tissue uptake process (plasma flow, dissociation from plasma binding proteins, influx, or intracellular elimination) is rate-limiting to the net tissue uptake of that hormone.
Familial ligand-defective apolipoprotein B. Identification of a new mutation that decreases LDL receptor binding affinity.
- C. Pullinger, L. Hennessy, J. Kane
- Biology, MedicineThe Journal of clinical investigation
- 1 March 1995
Deduced haplotypes using 10 apoB gene markers showed the Arg3531-->Cys alleles to be different in the two kindreds and indicates that the mutations arose independently.
Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis.
Noninferiority for these regimens was not shown, which indicates that shortening treatment to 4 months was not effective in this setting, and the two moxifloxacin-containing regimens produced a more rapid initial decline in bacterial load, as compared with the control group.
Sibutramine produces dose-related weight loss.
Sibutramine administered once daily for 24 weeks in the weight loss phase of treatment for uncomplicated obesity produced dose-related weight loss and was well tolerated, including small mean increases in blood pressure and heart rate.
Efficacy and safety of sibutramine in obese white and African American patients with hypertension: a 1-year, double-blind, placebo-controlled, multicenter trial.
In obese patients with controlled hypertension, sibutramine was an effective and well-tolerated treatment for weight loss and maintenance and was associated with significant improvements in serum levels of triglycerides, HDL-C, glucose, and uric acid.
14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: a randomised trial
Treatment of Highly Drug-Resistant Pulmonary Tuberculosis.
The combination of bedaquiline, pretomanid, and linezolid led to a favorable outcome at 6 months after the end of therapy in a high percentage of patients with highly drug-resistant forms of tuberculosis; some associated toxic effects were observed.
Effect of free fatty acids on the concentration of free thyroxine in human serum: the role of albumin.
- C. Mendel, P. Frost, R. Cavalieri
- Medicine, BiologyThe Journal of clinical endocrinology and…
- 1 December 1986
The concentration of FFA in normal human plasma in vivo generally ranges between 0.2 and 0.7 meq/liter; slightly higher concentrations have occasionally been reported in patients who are seriously…
Effects of sibutramine on body weight and serum lipids: a double-blind, randomized, placebo-controlled study in 322 overweight and obese patients with dyslipidemia.
In overweight and obese patients with high serum triglyceride levels and low serum HDL-C levels, treatment with sibutramine was associated with significant improvements in body weight and in serum cholesterol levels.
Randomized Dose-Ranging Study of the 14-Day Early Bactericidal Activity of Bedaquiline (TMC207) in Patients with Sputum Microscopy Smear-Positive Pulmonary Tuberculosis
The finding of a linear trend for dose suggests that the highest dose compatible with safety considerations should be taken forward to longer-term clinical studies.