• Publications
  • Influence
The free hormone hypothesis: a physiologically based mathematical model.
  • C. Mendel
  • Biology, Medicine
  • Endocrine reviews
  • 1 August 1989
The free hormone hypothesis states that the biological activity of a given hormone is affected by its unbound (free) rather than protein-bound concentration in the plasma. The fundamentalExpand
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Familial ligand-defective apolipoprotein B. Identification of a new mutation that decreases LDL receptor binding affinity.
Detection of new ligand-defective mutations of apolipoprotein B (apoB) will enable identification of sequences involved in binding to the LDL receptor. Genomic DNA from patients attending a lipidExpand
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Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis.
BACKGROUND Early-phase and preclinical studies suggest that moxifloxacin-containing regimens could allow for effective 4-month treatment of uncomplicated, smear-positive pulmonary tuberculosis. Expand
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Sibutramine produces dose-related weight loss.
OBJECTIVE Sibutramine is a weight control drug that inhibits the reuptake of both serotonin and norepinephrine. In animals, it reduces food intake and increases thermogenesis and preliminary data inExpand
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Efficacy and safety of sibutramine in obese white and African American patients with hypertension: a 1-year, double-blind, placebo-controlled, multicenter trial.
BACKGROUND Obesity is a highly prevalent medical condition and is commonly accompanied by hypertension. This study assessed the efficacy and safety of treatment with sibutramine hydrochloride forExpand
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Efficiency and safety of the combination of moxifloxacin, pretomanid (PA-824), and pyrazinamide during the first 8 weeks of antituberculosis treatment: a phase 2b, open-label, partly randomised trial
BACKGROUND New antituberculosis regimens are urgently needed to shorten tuberculosis treatment. Following on from favourable assessment in a 2 week study, we investigated a novel regimen for efficacyExpand
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Effect of free fatty acids on the concentration of free thyroxine in human serum: the role of albumin.
The concentration of FFA in normal human plasma in vivo generally ranges between 0.2 and 0.7 meq/liter; slightly higher concentrations have occasionally been reported in patients who are seriouslyExpand
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Randomized Dose-Ranging Study of the 14-Day Early Bactericidal Activity of Bedaquiline (TMC207) in Patients with Sputum Microscopy Smear-Positive Pulmonary Tuberculosis
ABSTRACT Bedaquiline is a new antituberculosis agent targeting ATP synthase. This randomized, double-blinded study enrolling 68 sputum smear-positive pulmonary tuberculosis patients evaluated theExpand
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Efficacy and Safety of Sibutramine in Obese White and African American Patients With Hypertension
Patients and Methods: Obese patients with a body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters) between 27 and 40 and a history of hypertensionExpand
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The free hormone hypothesis. Distinction from the free hormone transport hypothesis.
  • C. Mendel
  • Chemistry, Medicine
  • Journal of andrology
  • 4 March 1992
I. The free hormone transport hypothesis: distinction from the free hormone hypothesis. II. The free hormone hypothesis: importance of the rate-limiting step in tissue uptake. III. ExplicitExpand
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