• Publications
  • Influence
Evaluation of deuterated cholesterol and deuterated sitostanol for measurement of cholesterol absorption in humans.
The new method modified by using markers labeled with stable isotopes for measurement of dietary cholesterol absorption is extremely safe and reproducible without radioactive exposure to the subjects and labortory staff and can be used on women of child-bearing age. Expand
Identification of thiodiglycolic acid, thiodiglycolic acid sulfoxide, and (3-carboxymethylthio)lactic acid as major human biotransformation products of S-carboxymethyl-L-cysteine.
Results demonstrate the existence of a pyruvate-like metabolic pathway and suggest the necessity of a revision of the hitherto accepted biotransformation route of CMC in humans. Expand
Re-evaluation of the metabolism of carbocisteine in a British white population.
It has been claimed that the amino acid derivative carbocisteine is predominantly metabolized by sulfoxidation and that this pathway exhibits a genetic polymorphism. Moreover, those subjects with aExpand
Tandem mass spectrometric determination of 11-dehydrothromboxane B2, an index metabolite of thromboxane B2 in plasma and urine.
11-dehydro-TXB2 appears at present to be the best index metabolite of systemic TXA2 activity in plasma as well as in urine. Expand
Identification of novel arachidonic acid metabolites formed by prostaglandin H synthase.
HPLC analysis confirmed that arachidonic acid (20:4) was extensively converted into prostaglandin G2 and/or prostaglandsin H2 (PGH2) but several minor labelled products were formed in addition and allowed to conclude on PGH synthase mechanism and its intermediates for which an extended reaction scheme is proposed. Expand
Smoking alters thromboxane metabolism in man.
Significant alterations in the thromboxane A2 metabolite pattern were found in the urines of smokers, and cotinine, the major urinary metabolite of nicotine that correlates well with the reported daily cigarette consumption, showed a good correlation to throm boxane A1 metabolite excretion. Expand
Polyamine Changes in Reversible Cerebral Ischemia
It is suggested that the accumulation of putrescine during postischemic recirculation may be responsible for the delayed neuronal death occurring after ischemia. Expand
Enantiomer/enantiomer interaction of (S)- and (R)-propafenone for cytochrome P450IID6-catalyzed 5-hydroxylation: in vitro evaluation of the mechanism.
The enantiomers of propafenone interact with respect to 5-hydroxylation, with (R)-propafen one being a more potent inhibitor than the S-enantiomer with respectto cytochrome P450IID6-mediated 5-Hydroxylations. Expand
Identification of the "major" polymorphic carbocysteine metabolite as S-(carboxymethylthio)-L-cysteine.
Abstract The metabolism of the mucolytic agent carbocysteine ( S- carboxymethyl- l -cysteine , CMC) has attracted substantial interest during recent years [1]. It has been reported thatExpand
The infusion of trieicosapentaenoyl-glycerol into humans and the in vivo formation of prostaglandin I3 and thromboxane A3.
Because PGI3 was produced without involvement of intestinal absorption of eicosapentaenoic acid (EPA), enhanced P GI3 formation was strongly suggested to take place in the vasculature. Expand