Exercise Augmentation of Exposure Therapy for PTSD: Rationale and Pilot Efficacy Data
- Mark B. Powers, Johnna L Medina, J. Smits
- Psychology, BiologyCognitive Behaviour Therapy
- 23 February 2015
This pilot study provides initial support for further investigation into exercise augmented exposure therapy and shows that the PE+E group showed a greater improvement in PTSD symptoms and elevated BDNF relative to the PE only condition.
Memory-influencing intra-basolateral amygdala drug infusions modulate expression of Arc protein in the hippocampus.
- C. McIntyre, T. Miyashita, J. D. McGaugh
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 26 July 2005
It is shown that amygdala modulation of Arc protein and synaptic plasticity in efferent brain regions occurs at a posttranscriptional level, and infusions of Arc antisense oligodeoxynucleotides into the dorsal hippocampus impaired performance of an inhibitory avoidance task, indicating that the changes in Arc protein expression are related to the observed changes in memory performance.
Glucocorticoid Effects on Memory Consolidation Depend on Functional Interactions between the Medial Prefrontal Cortex and Basolateral Amygdala
- B. Roozendaal, Jayme R. McReynolds, E. A. van der Zee, Sangkwan Lee, J. D. McGaugh, C. McIntyre
- Biology, PsychologyJournal of Neuroscience
- 11 November 2009
Findings indicate that glucocorticoid effects on memory consolidation depend on bidirectional interactions between the BLA and the medial prefrontal cortex, a brain region involved in higher-order cognitive and affective processing.
Role of the Basolateral Amygdala in Memory Consolidation
- C. McIntyre, A. E. Power, B. Roozendaal, J. D. McGaugh
- Psychology, BiologyAnnals of the New York Academy of Sciences
- 1 April 2003
The findings suggest further that this memory‐modulatory system may be involved in the formation of traumatic memories and posttraumatic stress disorder in human subjects.
Amygdala Modulation of Memory Consolidation: Interaction with Other Brain Systems
- J. D. McGaugh, C. McIntyre, A. E. Power
- Biology, PsychologyNeurobiology of Learning and Memory
- 1 November 2002
Evidence from several experiments indicates that activation of the basolateral amygdala plays an essential role in modulating memory consolidation processes involving other brain regions, providing strong support for the hypothesis that the BLA plays a critical role in regulating the consolidation of lasting memories of significant experiences.
Rapid Remission of Conditioned Fear Expression with Extinction Training Paired with Vagus Nerve Stimulation
- David F. Peña, N. Engineer, C. McIntyre
- Psychology, BiologyBiological Psychiatry
- 1 June 2013
Interacting brain systems modulate memory consolidation
- C. McIntyre, J. D. McGaugh, Cedric L. Williams
- Biology, PsychologyNeuroscience and Biobehavioral Reviews
- 1 August 2012
Cholinergic modulation of memory in the basolateral amygdala involves activation of both m1 and m2 receptors
- A. E. Power, C. McIntyre, A. Litmanovich, J. D. McGaugh
- Biology, PsychologyBehavioural Pharmacology
- 1 May 2003
Findings indicate that modulation of memory consolidation induced by cholinergic influences within the BLA requires activation of both m1 and m2 receptor synapses.
Amygdala norepinephrine levels after training predict inhibitory avoidance retention performance in rats
- C. McIntyre, T. Hatfield, J. D. McGaugh
- Biology, PsychologyEuropean Journal of Neuroscience
- 1 October 2002
The degree of activation of the noradrenergic system within the amygdala in response to a novel, emotionally arousing experience predicts the extent of long‐term memory for that experience.
Vagus nerve stimulation enhances extinction of conditioned fear and modulates plasticity in the pathway from the ventromedial prefrontal cortex to the amygdala
- David F. Peña, Jessica E. Childs, Shawn Willett, A. Vital, C. McIntyre, S. Kroener
- Biology, PsychologyFrontiers in Behavioral Neuroscience
- 18 September 2014
The present findings suggest that VNS promotes plasticity in the IL-BLA pathway to facilitate extinction of conditioned fear responses (CFRs) in rats.
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