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The normal population distribution of PRNP codon 129 polymorphism
Objectives – The common prion protein gene (PRNP) codon 129 polymorphism modifies the susceptibility to and the phenotype of prion diseases. However, no truly representative normal population‐basedExpand
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A critical evaluation of HIPE data.
Resource allocation and planning of future services is dependent on current volumes, making it imperative that procedural data is accurately recorded. We sought to evaluate the effectiveness of theExpand
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The patient knows best: significant change in the physical component of the Multiple Sclerosis Impact Scale (MSIS-29 physical)
Aim: The aims of this study were to determine the reliability, responsiveness and minimally important change score of the Multiple Sclerosis Impact Scale (MSIS)-29 physical using the ExpandedExpand
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Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis
Importance Within 2 decades of onset, 80% of untreated patients with relapsing-remitting multiple sclerosis (MS) convert to a phase of irreversible disability accrual termed secondary progressive MS.Expand
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Unrecognised symptoms of depression in a community–based population with multiple sclerosis
AbstractBackground and aimsThe association between multiple sclerosis (MS) and depression has been well established but prevalence estimates have varied widely. The aims of this study were to assessExpand
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Status of diagnostic approaches to AQP4-IgG seronegative NMO and NMO/MS overlap syndromes
Distinguishing aquaporin-4 IgG(AQP4-IgG)-negative neuromyelitis optica spectrum disorders (NMOSD) from opticospinal predominant multiple sclerosis (MS) is a clinical challenge with importantExpand
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Relating health-related Quality of Life to disability progression in multiple sclerosis, using the 5-level EQ-5D
Background: Increasing use of the Quality-Adjusted Life-Year to inform resource allocation decision-making has highlighted the importance of relating clinical and health-related quality of lifeExpand
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Synthesis of an apionucleoside family and discovery of a prodrug with anti-HIV activity.
We report the synthesis of a family of D- and L-furano-D-apionucleosides, their 3'-deoxy, as well as their 2',3'-dideoxy analogues with thymine and adenine nucleobases. Single carbon homologation ofExpand
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A preliminary validation of the brief international cognitive assessment for multiple sclerosis (BICAMS) tool in an Irish population with multiple sclerosis (MS).
BACKGROUND Cognitive impairment is common in multiple sclerosis (MS) irrespective of disease stage or subtype. It is typically underreported and neuropsychological testing can be required to detectExpand
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Economic costs associated with an MS relapse.
BACKGROUND Multiple sclerosis (MS) commonly affects young adults and can be associated with significant disability resulting in considerable socioeconomic burden for both patient and society. AIMSExpand
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