C. McDougle

Publications478
h-index91
Citations28,928
Highly Influential Citations1,177
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Functional impact of global rare copy number variation in autism spectrum disorders
TLDR
The genome-wide characteristics of rare (<1% frequency) copy number variation in ASD are analysed using dense genotyping arrays to reveal many new genetic and functional targets in ASD that may lead to final connected pathways.
View on Nature
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
TLDR
Several new susceptibility genes encoding neuronal cell-adhesion molecules, including NLGN1 and ASTN2, were enriched with CNVs in ASD cases compared to controls, and duplications 55 kilobases upstream of complementary DNA AK123120 indicate that these two important gene networks expressed within the central nervous system may contribute to the genetic susceptibility of ASD.
View on Nature
Parent-Rated Anxiety Symptoms in Children with Pervasive Developmental Disorders: Frequency and Association with Core Autism Symptoms and Cognitive Functioning
TLDR
It is suggested that parent ratings could be a useful source of information about anxiety symptoms in this population of children with PDD, and some anxiety symptoms such as phobic and social anxiety may be closer to core symptoms of PDD.
View on Springer
Family accommodation in obsessive-compulsive disorder.
TLDR
Family accommodation of patients with obsessive-compulsive disorder was associated with global family dysfunction and stress and it is suggested that families' efforts to accommodate patients may be intended to reduce patient anxiety or anger directed at relatives.
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Symptoms of obsessive-compulsive disorder.
TLDR
The four symptom dimensions identified in this study are largely congruent with those identified in earlier reports, and may be of value in future genetic, neurobiological, and treatment response studies.
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Tryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects
View on Nature
Risperidone in children with autism and serious behavioral problems.
TLDR
Risperidone was effective and well tolerated for the treatment of tantrums, aggression, or self-injurious behavior in children with autistic disorder and the benefit was maintained at six months.
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A genome-wide scan for common alleles affecting risk for autism
TLDR
In one of four primary association analyses, the association signal for marker rs4141463, located within MACROD2, crossed the genome-wide association significance threshold of P < 5 × 10−8 and, consistent with the winner's curse, its effect size in the replication sample was much smaller.
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A double-blind, placebo-controlled study of risperidone addition in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder.
TLDR
It is suggested that OCD patients with and without comorbid chronic tic disorders or schizotypal personality disorder may respond to the addition of low-dose risperidone to ongoing SRI therapy.
View on PubMed
Individual common variants exert weak effects on the risk for autism spectrum disorders
TLDR
Stage 2 of the Autism Genome Project genome-wide association study is reported, adding 1301 ASD families and bringing the total to 2705 families analysed, and it is reasonable to conclude that common variants affect the risk for ASD but their individual effects are modest.
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