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Glutamate Receptor Ion Channels: Structure, Regulation, and Function
TLDR
This review discusses International Union of Basic and Clinical Pharmacology glutamate receptor nomenclature, structure, assembly, accessory subunits, interacting proteins, gene expression and translation, post-translational modifications, agonist and antagonist pharmacology, allosteric modulation, mechanisms of gating and permeation, roles in normal physiological function, as well as the potential therapeutic use of pharmacological agents acting at glutamate receptors.
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Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation
TLDR
It is demonstrated that long-term potentiation in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs, which are physiologically expressed at CA1Pyramidal cell synapses during LTP, and may be required for LTP consolidation.
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Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing
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The Role of the GluR2 Subunit in AMPA Receptor Function and Synaptic Plasticity
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Differential Mechanisms of Transmission at Three Types of Mossy Fiber Synapse
TLDR
Induction of LTP or LTD altered the short-term plasticity of transmission onto both pyramidal cells and interneuron CP AMPA synapses by a mechanism consistent with changes in release probability, revealing differential mechanisms of transmission at three classes of mossy fiber synapse made onto distinct targets.
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Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion
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Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality
TLDR
An essential, dosage-sensitive neuronal-specific role for Pafah1b1 in neuronal migration throughout the brain, and an essential role in early embryonic development are demonstrated.
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A Blueprint for the Spatiotemporal Origins of Mouse Hippocampal Interneuron Diversity
TLDR
It is found that hippocampal interneurons are produced in two neurogenic waves between E9–E12 and E12–E16 from MGE and CGE, respectively, and invade the hippocampus by E14, which provides a basic blueprint of the developmental origins of hippocampalinterneuron diversity.
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Interneurons unbound
TLDR
This review brings together recently described properties and emerging principles of interneuron function that indicate a much more complex role for these cells than just providers of inhibition.
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Hippocampal GABAergic Inhibitory Interneurons.
TLDR
An overview of the current state of the field of interneuron research, focusing largely on the hippocampus, discusses recent advances related to the various cell types, including their development and maturation, expression of subtype-specific voltage- and ligand-gated channels, and their roles in network oscillations.
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