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Insulin signaling to the glomerular podocyte is critical for normal kidney function.
Diabetic nephropathy (DN) is the leading cause of renal failure in the world. It is characterized by albuminuria and abnormal glomerular function and is considered a hyperglycemic "microvascular"Expand
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Signalling, cycling and desensitisation of gonadotrophin-releasing hormone receptors.
Sustained stimulation of G-protein-coupled receptors (GPCRs) typically causes receptor desensitisation, which is mediated by phosphorylation, often within the C-terminal tail of the receptor. TheExpand
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Involvement of PKCα and G‐protein‐coupled receptor kinase 2 in agonist‐selective desensitization of µ‐opioid receptors in mature brain neurons
Background and purpose:  The ability of an agonist to induce desensitization of the µ‐opioid receptor (MOR) depends upon the agonist used. Furthermore, previous data suggest that the intracellularExpand
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Effects of pituitary adenylate cyclase-activating polypeptide in the pituitary: activation of two signal transduction pathways in the gonadotrope-derived alpha T3-1 cell line.
Pituitary adenylate cyclase-activating polypeptide (PACAP) is thought to play a hypophysiotropic role, but little is known of the identity of PACAP-stimulated cells in the pituitary, the nature ofExpand
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Spatiotemporal Regulation of ERK2 by Dual Specificity Phosphatases*S⃞
Although many stimuli activate extracellular signal-regulated kinases 1 and 2 (ERK1/2), the kinetics and compartmentalization of ERK1/2 signals are stimulus-dependent and dictate physiologicalExpand
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ATP-Mediated Killing of Mycobacterium bovis Bacille Calmette-Guérin Within Human Macrophages Is Calcium Dependent and Associated with the Acidification of Mycobacteria-Containing Phagosomes1
We previously demonstrated that extracellular ATP stimulated macrophage death and mycobacterial killing within Mycobacterium bovis Bacille Calmette-Guérin (BCG)-infected human macrophages. ATPExpand
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The molecular mechanism of action of gonadotropin releasing hormone (GnRH) in the pituitary.
Publisher Summary Gonadotropin-releasing hormone (GnRH) is released by the hypothalamus and travels, via a portal system, to the pituitary. Here it stimulates the release of luteinizing hormone (LH)Expand
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Asn102 of the Gonadotropin-releasing Hormone Receptor Is a Critical Determinant of Potency for Agonists Containing C-terminal Glycinamide*
We demonstrate a critical role for Asn102 of the human gonadotropin-releasing hormone (GnRH) receptor in the binding of GnRH. Mutation of Asn102, located at the top of the second transmembrane helix,Expand
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Seven-transmembrane receptor signalling and ERK compartmentalization
Vast numbers of extracellular signalling molecules exert effects on their target cells by activation of a relatively limited number of mitogen-activated protein kinase (MAPK) cascades, raising theExpand
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Evidence for a role of pituitary ATP receptors in the regulation of pituitary function.
Despite a rapidly increasing acceptance for a role of ATP as an extracellular mediator in several biological systems, the present report shows that ATP may mediate physiological responses inExpand
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