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Second consensus statement on the diagnosis of multiple system atrophy
TLDR
New criteria for diagnosis of multiple system atrophy have simplified the previous criteria, have incorporated current knowledge, and are expected to enhance future assessments of the disease.
Consensus statement on the diagnosis of multiple system atrophy
Human cingulate cortex and autonomic control: converging neuroimaging and clinical evidence.
TLDR
Converging neuroimaging and clinical findings suggest that ACC function mediates context-driven modulation of bodily arousal states during effortful cognitive and motor behaviour.
Cerebral correlates of autonomic cardiovascular arousal: a functional neuroimaging investigation in humans
TLDR
Evidence is provided for the involvement of areas previously implicated in cognitive and emotional behaviours in the representation of peripheral autonomic states, consistent with a functional organization that produces integrated cardiovascular response patterns in the service of volitional andotional behaviours.
EFNS guidelines on the diagnosis and management of orthostatic hypotension
TLDR
Evidence based guidelines for the diagnostic workup and the therapeutic management (non‐pharmacological and pharmacological) are provided based on the EFNS guidance regulations.
Clinical usefulness of magnetic resonance imaging in multiple system atrophy
OBJECTIVES To determine the sensitivity, specificity, and positive predictive values of a selection of abnormal findings in the putamen and infratentorial structures on routine magnetic resonance
[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy
TLDR
Increased [11C](R)-PK11195 binding was primarily found in the dorsolateral prefrontal cortex, putamen, pallidum, pons, and substantia nigra, reflecting the known distribution of neuropathologic changes in MSA.
Presentation, diagnosis, and management of multiple system atrophy in Europe: Final analysis of the European multiple system atrophy registry
TLDR
This largest clinical series of MSA patients reported so far shows that the disease presents uniformly across Europe, and the observed differences in diagnostic and therapeutic management including lack of therapy for dysautonomia emphasize the need for future guidelines in these areas.
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