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Acute toxicity studies with insect attractants.
Abstract Eight insect attractants and one inhibitor of a sex attractant were tested for acute oral and aerosol inhalation toxicity in rats, for acute dermal toxicity, eye irritation, and primary skinExpand
In vivo oestrogenicity and binding characteristics of alpha-zearalanol (P-1496) to different classes of oestrogen binding proteins in rat liver.
TLDR
Striking similarities are shown between the binding of P-1496 and oestradiol-17 beta to liver oestrogen receptor in vitro and in vivo, but differences are observed with respect to their binding to other cytoplasmic components of liver. Expand
Structure-activity relationship study of steroidal and nonsteroidal inhibitors of the enzyme estrone sulfatase.
TLDR
It is concluded that the C(17) polar group may not be necessary for inhibitory activity and that the only requirement appears to be the mimicking of the steroid C(3) sulfonate group. Expand
Polyamine and thiol metabolism in Trypanosoma granulosum: similarities with Trypanosoma cruzi.
TLDR
This first report of polyamines and low molecular mass thiols in Trypanosoma granulosum indicates intriguing similarities with the metabolism of the human pathogen TrypanOSoma cruzi. Expand
Early events in the response of fast skeletal muscle to chronic low-frequency stimulation. Polyamine biosynthesis and protein phosphorylation.
TLDR
During the early stages of stimulation, no prominent changes were seen either in the phosphorylation pattern or in the activity of cyclic AMP-dependent protein kinase, but these characteristics changed significantly at a later stage and became indistinguishable from those of slow muscle by 3 to 4 weeks of stimulation. Expand
Experiments with growth of the eel trypanosome, Trypanosoma granulosum Laveran & Mesnil, 1902, in semi-defined and defined media
TLDR
In vitro experiments with D, L-alpha-difluoromethylomithine (DFMO) showed morphological changes leading to destruction of the trypanosome with increasing concentrations of the drug. Expand
Nuclear interactions of zearalanol-oestrogen receptor complexes in rat liver: a comparison with oestradiol-17 beta.
TLDR
P-1496 is capable of causing retention of oestrogen receptor by liver nuclei and it binds to DNA in a manner similar to E2, suggesting close similarities in non-covalent DNA binding between the two compounds, in both males and females. Expand
Uptake of putrescine by Trypanosoma granulosum.
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