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Heterogeneity of thromboxane A2 (TP‐) receptors: evidence from antagonist but not agonist potency measurements
TLDR
The excellent agreement for both full and partial agonist potencies between the six preparations provides no evidence for TP‐receptor subtypes and further suggests that the agonist recognition sites of the TP‐ receptors could be very similar, if not identical, in nature. Expand
Endothelins and rat carotid body: autoradiographic and functional pharmacological studies.
TLDR
The effects of ET-1 on ventilation, coupled with the presence of ET binding sites in areas involved in respiratory and cardiovascular regulation, is consistent with a physiological role for ET in the control of respiration, but evidence suggests that ET is not crucial for chemotransduction in acute hypoxia. Expand
Effects of aspirin on prostaglandin and fructose levels in human semen.
Synthesis of oxabicyclo[2.2.1]heptane prostanoids having thromboxane-like activity at sub-nanomolar concentrations
Abstract Prostanoids with an oxabicyclo[2.2.1]heptane ring system and a 15-hydroxy-16- p -fluorophenoxy ω-chain have been synthesised. One analogue 17d has the highest thromboxane-like agonistExpand
THROMBOXANE-LIKE ACTIVITY OF PROSTANOIDS WITH AROMATIC SUBSTITUENTS AT C16 AND C17
ABSTRACT Replacement of the C17-C20 unit in PGD 2 , PGF 2α , 9, 11-etheno and 9, 11- ethano PGH 2 with a p-fluorophenoxy moiety markedly increases TXA 2 -like activity. The etheno and ethanoExpand
Characterization of the EP-receptor mediating dilatation and potentiation of inflammation in rabbit skin.
TLDR
It is suggested that vasodilatation is a major mechanism of PGE-induced potentiation of plasma exudation and that an EP2-receptor subtype is involved, however, the possibility of a second non-dilator mechanism could not be ruled out. Expand
Effects of endothelins on respiration and arterial chemoreceptor activity in anaesthetised rats.
The endothelins (ETs) are a family of peptides (ET-1, ET-2, ET-3) that can be released from the endothelium by hypoxia. Two subtypes of ET receptor have been identified - ETA and ETB (see Haynes etExpand
Diphenylmethylazine prostanoids with prostacyclin-like actions on human platelets.
TLDR
A structure-activity study has been performed with respect to EP 157, a PGH2 analogue with a diphenylmethoxime omega-chain which behaves as an IP-receptor agonist, and the results are discussed in relation to octimibate, a triphenylimidazoloxyalkanoic acid, and to the possibility of IP- receptor subtypes. Expand
Nitric oxide modulates articular sensory discharge and responsiveness to bradykinin in normal and arthritic rats in vivo
TLDR
Evidence is provided that nitric oxide modulates articular C-fibre activity and reduces responsiveness to bradykinin, which is implicated in peripheral nociceptive processing. Expand
ACTIONS OF 16‐ARYLOXY ANALOGUES OF PROSTAGLANDIN F2α ON PREPARATIONS RESPONSIVE TO PROSTAGLANDIN ENDOPEROXIDES
  • R. Jones, C. Marr
  • Biology, Medicine
  • British journal of pharmacology
  • 1 December 1977
On four prostaglandin endoperoxide‐sensitive preparations, namely human platelets in vitro, rabbit aortic strip, guinea‐pig tracheal chain and pig blood pressure, ICI 79939 and its 11‐oxo analogueExpand
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