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Heterogeneity of thromboxane A2 (TP‐) receptors: evidence from antagonist but not agonist potency measurements
- P. Tymkewycz, R. L. Jones, N. H. Wilson, C. Marr
- Biology, MedicineBritish journal of pharmacology
- 1 March 1991
The excellent agreement for both full and partial agonist potencies between the six preparations provides no evidence for TP‐receptor subtypes and further suggests that the agonist recognition sites of the TP‐ receptors could be very similar, if not identical, in nature.
Endothelins and rat carotid body: autoradiographic and functional pharmacological studies.
Effects of aspirin on prostaglandin and fructose levels in human semen.
It is concluded that highly toxic doses of aspirin would be required to block prostaglandin synthesis completely and fructose levels were unaffected.
Synthesis of oxabicyclo[2.2.1]heptane prostanoids having thromboxane-like activity at sub-nanomolar concentrations
THROMBOXANE-LIKE ACTIVITY OF PROSTANOIDS WITH AROMATIC SUBSTITUENTS AT C16 AND C17
Characterization of the EP-receptor mediating dilatation and potentiation of inflammation in rabbit skin.
Effects of endothelins on respiration and arterial chemoreceptor activity in anaesthetised rats.
- D. McQueen, M. Dashwood, V. J. Cobb, C. Marr
- BiologyAdvances in experimental medicine and biology
The endothelins (ETs) are a family of peptides (ET-1, ET-2, ET-3) that can be released from the endothelium by hypoxia. Two subtypes of ET receptor have been identified - ETA and ETB (see Haynes et…
Diphenylmethylazine prostanoids with prostacyclin-like actions on human platelets.
- R. L. Jones, N. H. Wilson, C. Marr, G. Muir, R. Armstrong
- Chemistry, BiologyJournal of lipid mediators
- 1 March 1993
A structure-activity study has been performed with respect to EP 157, a PGH2 analogue with a diphenylmethoxime omega-chain which behaves as an IP-receptor agonist, and the results are discussed in relation to octimibate, a triphenylimidazoloxyalkanoic acid, and to the possibility of IP- receptor subtypes.
Nitric oxide modulates articular sensory discharge and responsiveness to bradykinin in normal and arthritic rats in vivo
Evidence is provided that nitric oxide modulates articular C-fibre activity and reduces responsiveness to bradykinin, which is implicated in peripheral nociceptive processing.
ACTIONS OF 16‐ARYLOXY ANALOGUES OF PROSTAGLANDIN F2α ON PREPARATIONS RESPONSIVE TO PROSTAGLANDIN ENDOPEROXIDES
On four prostaglandin endoperoxide‐sensitive preparations, namely human platelets in vitro, rabbit aortic strip, guinea‐pig tracheal chain and pig blood pressure, ICI 79939 and its 11‐oxo analogue…