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Identification of mitochondrial carriers in Saccharomyces cerevisiae by transport assay of reconstituted recombinant proteins.
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Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution.
TLDR
Unlike the yeast orthologue, SAMC catalysed virtually only countertransport, exhibited a higher transport affinity for SAM and was strongly inhibited by tannic acid and Bromocresol Purple.
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Identification and reconstitution of the yeast mitochondrial transporter for thiamine pyrophosphate
TLDR
The identification of the mitochondrial carrier for the essential cofactor thiamine pyrophosphate (ThPP) is described, which has been overexpressed in bacteria, reconstituted into phospholipid vesicles and identified by its transport properties.
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The insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth.
TLDR
It is shown that IGF-I and insulin induce rapid transcription of the mitochondrial pyrimidine nucleotide carrier PNC1, which shares significant identity with the essential yeast mitochondrial carrier Rim2p.
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A Novel Member of Solute Carrier Family 25 (SLC25A42) Is a Transporter of Coenzyme A and Adenosine 3′,5′-Diphosphate in Human Mitochondria*
TLDR
This work functionally identified and characterized SLC25A42, a novel human member of the mitochondrial carrier family, and is the first time that a mitochondrial carrier for CoA and adenosine 3′,5′-diphosphate has been characterized biochemically.
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Legionella pneumophila Secretes a Mitochondrial Carrier Protein during Infection
TLDR
A novel MCF member, termed Legionella nucleotide carrier Protein (LncP), was discovered encoded in the genome of Legionella pneumophila, the causative agent of Legionnaire's disease, andstrate transport studies on purified LncP reconstituted in liposomes revealed that it catalyzes unidirectional transport and exchange of ATP transport across membranes, thereby supporting a role for LncF as an ATP transporter.
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Identification and functional reconstitution of yeast mitochondrial carrier for S‐adenosylmethionine
TLDR
The genome of Saccharomyces cerevisiae contains 35 members of the mitochondrial carrier protein family, most of which have not yet been functionally identified but the corresponding gene has been overexpressed in bacteria and the protein has been reconstituted into phospholipid vesicles and identified by its transport properties.
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Intra-mitochondrial Methylation Deficiency Due to Mutations in SLC25A26
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α-Isopropylmalate, a Leucine Biosynthesis Intermediate in Yeast, Is Transported by the Mitochondrial Oxalacetate Carrier*
TLDR
Recombinant and reconstituted mitochondrial oxal acetate carrier (Oac1p) efficiently transported α-IPM in addition to its known substrates oxalacetate, sulfate, and malonate and in contrast to other di- and tricarboxylate transporters as well as the previously proposed α- IPM transporter.
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A novel mutation in the SLC25A15 gene in a Turkish patient with HHH syndrome: Functional analysis of the mutant protein
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