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Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells
- S. Chiesa, S. Morbelli, A. Uccelli
- BiologyProceedings of the National Academy of Sciences
- 29 September 2011
It is shown that murine MSC impair Toll-like receptor-4 induced activation of DC resulting in the inhibition of cytokines secretion, down-regulation of molecules involved in the migration to the lymph nodes, antigen presentation to CD4+ T cells, and cross-presentation to CD8+ T Cells.
Metformin selectively affects human glioblastoma tumor-initiating cell viability
Data clearly suggest that metformin exerts antiproliferative activity on glioblastoma cells, showing a higher specificity toward tumor-initiating cells, and that the inhibition of Akt pathway may represent a possible intracellular target of this effect.
Stress echocardiography and the human factor: the importance of being expert.
A fully organic retinal prosthesis restores vision in a rat model of degenerative blindness
The fabrication and functional validation of a fully organic prosthesis for long-term in vivo subretinal implantation in the eye of Royal College of Surgeons rats, a widely recognized model of Retinitis pigmentosa, highlights the possibility of developing a new generation of fully organic, highly biocompatible and functionally autonomous photovoltaic prostheses forSubretinal implants to treat degenerative blindness.
Metformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II
It is shown that metformin impairs the enzymatic function of HKI and II in Calu-1 cells, which results in mitochondrial depolarization and subsequent cell death.
Metformin, cancer and glucose metabolism.
- B. Salani, A. Del Rio, C. Marini, G. Sambuceti, R. Cordera, D. Maggi
- Biology, MedicineEndocrine-related cancer
- 1 December 2014
Recent findings on molecular mechanisms that sustain the anticancer effect of metformin through regulation of glucose metabolism are discussed, focused on the emerging action of met formin on glycolysis in normal and cancer cells, with a drug discovery perspective.
18F-NaF Uptake by Atherosclerotic Plaque on PET/CT Imaging: Inverse Correlation Between Calcification Density and Mineral Metabolic Activity
The concept that 18F-NaF is a feasible option in imaging molecular calcium deposition in the early stages of plaque formation, when active uptake mechanisms are the main determinants of calcium presence, is supported; however, the data suggest that non–attenuation-corrected reconstruction does not significantly affect evaluation of plaque of any thickness.
IGF1 regulates PKM2 function through Akt phosphorylation
It is shown that IGF1 can regulate glycolysis rate, stimulate PKM2 Ser/Thr phosphorylation and decrease cellular pyruvate kinase activity, suggesting a role of IGFIR/Akt axis in regulating gly colysis by Ser/ Thr PKM 2 phosphorylated in cancer cells.
Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
Findings indicate that the glucose and amino acid deficiency conditions imposed by STS promote an anti-Warburg effect characterized by increased oxygen consumption but failure to generate ATP, resulting in oxidative damage and apoptosis.
Myocardial contrast echocardiography versus dobutamine echocardiography for predicting functional recovery after acute myocardial infarction treated with primary coronary angioplasty.