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Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease
Summary.  After rupture of an arteriosclerotic plaque in a coronary artery, platelets play a crucial role in the subsequent thrombus formation, leading to myocardial infarction. An increased meanExpand
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Risk of pregnancy-associated recurrent venous thromboembolism in women with a history of venous thrombosis.
BACKGROUND Limited data exist on the risk of pregnancy-associated venous thromboembolism (VTE) in women with a history of VTE. OBJECTIVE To evaluate the risk of recurrent pregnancy-associatedExpand
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Polymorphisms of the inflammatory system and risk of ischemic cerebrovascular events
Abstract Background: Chronic and acute infections are associated with an increased risk of stroke. The inflammatory response can be influenced by functional polymorphisms in components of the immuneExpand
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Thrombin as a multi-functional enzyme. Focus on in vitro and in vivo effects.
Thrombin is the central protease in the coagulation cascade and one of the most extensively studied of all enzymes. In addition to its recognised role in the coagulation cascade and haemostasis,Expand
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Candidate genetic risk factors of stroke: results of a multilocus genotyping assay.
BACKGROUND Epidemiological studies indicate that genetic factors play a role in the risk of stroke, particularly in younger individuals, but the role of single-nucleotide polymorphisms (SNPs) isExpand
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High concentrations of soluble P-selectin are associated with risk of venous thromboembolism and the P-selectin Thr715 variant.
BACKGROUND The cell adhesion molecule P-selectin has an important role in the pathophysiology of thrombosis. The effect on venous thromboembolism (VTE) of increased circulating concentrations ofExpand
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Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy.
Toll-like receptor 4 (TLR4) is required for efficient recognition of bacterial infections. We investigated an association between 2 TLR4 mutations (Asp(299)Gly and Thr(399)Ile) and meningococcalExpand
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C677T MTHFR mutation and factor V Leiden mutation in patients with TIA/minor stroke: a case-control study.
A common C677T mutation in the gene for the enzyme 5,10-methylenetetrahydrofolate reductase (5,10-MTHFR) has been linked to elevated levels of homocysteine and was therefore suspected to be aExpand
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Evaluation of RNA Isolation Methods and Reference Genes for RT-PCR Analyses of Rare Target RNA
Abstract Reverse transcription polymerase chain reaction (RTPCR) analysis is increasingly becoming part of the diagnostic and prognostic evaluation for hematologic and oncologic disorders. Currently,Expand
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Factor V Leiden mutation carriership and venous thromboembolism in polycythemia vera and essential thrombocythemia
Polycythemia Vera (PV) and Essential Thrombocythemia (ET) are chronic myeloproliferative disorders complicated by a high incidence of thrombotic complications. Extensive coagulation studies failed toExpand
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