C. Mann

Publications71
h-index36
Citations4,589
Highly Influential Citations302
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G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast.
TLDR
A suppressor analysis indicated that G1-cyclin stabilization in grr1 was not a consequence of the nutrient uptake defect, suggesting that the GRR1 gene product is part of a common regulatory pathway linking two functions important for cell growth, nutrient uptake, and G1 cyclin-controlled cell division.
Mitotic stability of yeast chromosomes: A colony color assay that measures nondisjunction and chromosome loss
S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase
TLDR
It is shown here that CIM5 is the functional yeast homologue of the human MSS1 protein3 and that homologues of CIM3 and Cim5 are present in a highly purified preparation of the Drosophila 26S protease4.
Regulation of cytokinesis by the Elm1 protein kinase in Saccharomyces cerevisiae.
TLDR
Genetic and biochemical evidence suggest that Elm1 and the three other septin-localised protein kinases work in parallel pathways to regulate septin behaviour and cytokinesis in budding yeast is regulated by Elm1.
The SLT2(MPK1) MAP kinase is activated during periods of polarized cell growth in yeast.
TLDR
It is found that the SLT2 kinase is tyrosine phosphorylated and activated during periods in which yeast cells are undergoing polarized cell growth, namely during bud formation of vegetative cell division and during projection formation upon treatment with mating pheromone.
Civ1 (CAK In Vivo), a Novel Cdk-Activating Kinase
Sgt1p Contributes to Cyclic AMP Pathway Activity and Physically Interacts with the Adenylyl Cyclase Cyr1p/Cdc35p in Budding Yeast
TLDR
It is shown here that Sgt1p is also involved in the cyclic AMP (cAMP) pathway in Saccharomyces cerevisiae and that the activity of the cAMP pathway is affected in an sgt1 conditional mutant.
The SLT2 (MPK1) MAP kinase homolog is involved in polarized cell growth in Saccharomyces cerevisiae
TLDR
Slt2 mutants exhibit phenotypes similar to those shown by mutants of the yeast actin cytoskeleton, including delocalization of chitin deposition and of actin cortical spots and the accumulation of secretory pathway membranes and vesicles, which are suggested to function downstream or in parallel with Cdc28p in promoting bud formation and apical growth.
Structural basis for the interaction of Asf1 with histone H3 and its functional implications
TLDR
Direct experimental evidence of the mode of binding between a histone and one of its chaperones and genetic data suggesting that this interaction is important in both the DNA damage response and transcriptional silencing are obtained.
Yeast homolog of a cancer‐testis antigen defines a new transcription complex
TLDR
Evidence is provided that Pcc1p is a new transcription factor and that its mutation affects expression of several genes, some of which are involved in cell cycle progression and polarized growth.
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