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G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast.
Entry into a new cell cycle is triggered by environmental signals at a point called Start in G1 phase. A key regulator of this transition step in yeast is the CDC28 kinase together with itsExpand
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S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase
WE isolated two mutants from the yeast Saccharomyces cerevisiae,cim3-1 and cim5-1, that arrest cell division in G2/metaphase at 37 °C. CIM3 (identical to SUG1; ref. 1) and CIM5 are similar to eachExpand
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Regulation of cytokinesis by the Elm1 protein kinase in Saccharomyces cerevisiae.
A Saccharomyces cerevisiae mutant unable to grow in a cdc28-1N background was isolated and shown to be affected in the ELM1 gene. Elm1 is a protein kinase, thought to be a negative regulator ofExpand
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Mitotic stability of yeast chromosomes: A colony color assay that measures nondisjunction and chromosome loss
A colony color assay that measures chromosome stability is described and is used to study several parameters affecting the mitotic maintenance of yeast chromosomes, including ARS function, CENExpand
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Civ1 (CAK In Vivo), a Novel Cdk-Activating Kinase
Cyclin-dependent protein kinases (Cdks) play key roles in regulating cell division and gene expression. Most Cdks require binding of a cyclin and phosphorylation by a Cdk-activating kinase (CAK) toExpand
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Structural basis for the interaction of Asf1 with histone H3 and its functional implications
Asf1 is a conserved histone chaperone implicated in nucleosome assembly, transcriptional silencing, and the cellular response to DNA damage. We solved the NMR solution structure of the N-terminalExpand
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Sgt1p Contributes to Cyclic AMP Pathway Activity and Physically Interacts with the Adenylyl Cyclase Cyr1p/Cdc35p in Budding Yeast
ABSTRACT Sgt1p is a highly conserved eucaryotic protein that is required for both SCF (Skp1p/Cdc53p-Cullin-F-box)-mediated ubiquitination and kinetochore function in yeast. We show here that Sgt1p isExpand
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Yeast homolog of a cancer‐testis antigen defines a new transcription complex
We have isolated a new yeast gene (PCC1) that codes for a factor homologous to human cancer‐testis antigens. We provide evidence that Pcc1p is a new transcription factor and that its mutation affectsExpand
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Cell cycle restriction of telomere elongation
Telomere elongation by telomerase balances the progressive shortening of chromosome ends due to the succession of replication cycles [1] [2]. Telomerase activity is regulated in vivo at its site ofExpand
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The SLT2 (MPK1) MAP kinase homolog is involved in polarized cell growth in Saccharomyces cerevisiae
Bud emergence, spindle pole body duplication and DNA replication are all dependent on the activation of the CDC28 protein kinase at the Start point in the G1 phase of the cell cycle. Bud emergenceExpand
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