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- Publications
- Influence
Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade
Withaferin A (WA) is present abundantly in Withania somnifera, a well-known Indian medicinal plant. Here we demonstrate how WA exhibits a strong growth-inhibitory effect on several human leukemic… Expand
Preoperative Glycosylated Hemoglobin: A Risk Factor for Patients Undergoing Coronary Artery Bypass.
- P. Narayan, Sarang Kshirsagar, +7 authors M. Das
- Medicine
- The Annals of thoracic surgery
- 1 August 2017
BACKGROUND
The prevalence of diabetes in the population of patients presenting with coronary artery disease continues to rise. The aim of this study was to assess whether high Glycosylated hemoglobin… Expand
Investigation of 9‐o‐acetylated sialoglycoconjugates in childhood acute lymphoblastic leukaemia
- C. Mandal, M. Chatterjee, D. Sinha
- Medicine
- British journal of haematology
- 1 September 2000
Modern treatment protocols of childhood acute lymphoblastic leukaemia (ALL) utilize the biological and clinical features of the disease to tailor the intensity of therapy to the risk of relapse by… Expand
Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38…
- S. Mondal, C. Mandal, R. Sangwan, Sarmila Chandra, C. Mandal
- Biology, Medicine
- Molecular Cancer
- 13 September 2010
BackgroundCeramide is an important second messenger that has diverse cellular and biological effect. It is a specific and potent inducer of apoptosis and suppressor of cell growth. In leukemia,… Expand
O‐acetylation of GD3 prevents its apoptotic effect and promotes survival of lymphoblasts in childhood acute lymphoblastic leukaemia
- Kankana Mukherjee, A. K. Chava, +4 authors C. Mandal
- Biology, Medicine
- Journal of cellular biochemistry
- 15 October 2008
We have previously demonstrated induction of O‐acetylated sialoglycoproteins on lymphoblasts of childhood acute lymphoblastic leukaemia (ALL). These molecules promote survival of lymphoblasts by… Expand
9-O-acetylated GD3 triggers programmed cell death in mature erythrocytes.
- Kankana Mukherjee, S. Chowdhury, +4 authors C. Mandal
- Biology, Medicine
- Biochemical and biophysical research…
- 26 October 2007
An acetylated modification of a tumor-associated ganglioside GD3 (9-O-AcGD3) is expressed in certain tumors and present during early stages of development in different tissues. However, the status… Expand
Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition
- Biswajit Khatua, A. Ghoshal, +4 authors C. Mandal
- Biology, Medicine
- FEBS letters
- 5 February 2010
The opportunism of Pseudomonas aeruginosa (PA) in immunocompromised hosts prompted us to explore the potential role of sialic acids (Sia) in this phenomenon. Culture of PA in the presence of… Expand
High level of sialate-O-acetyltransferase activity in lymphoblasts of childhood acute lymphoblastic leukaemia (ALL): enzyme characterization and correlation with disease status
- C. Mandal, G. V. Srinivasan, +4 authors C. Mandal
- Biology, Medicine
- Glycoconjugate Journal
- 2008
Previous studies had established an over-expression of 9-O-acetylated sialoglycoproteins (Neu5,9Ac2-GPs) on lymphoblasts of childhood acute lymphoblastic leukaemia (ALL). Here, we report the… Expand
Down regulation of membrane‐bound Neu3 constitutes a new potential marker for childhood acute lymphoblastic leukemia and induces apoptosis suppression of neoplastic cells
- C. Mandal, C. Tringali, +4 authors C. Mandal
- Biology, Medicine
- International journal of cancer
- 15 January 2010
Membrane‐linked sialidase Neu3 is a key enzyme for the extralysosomal catabolism of gangliosides. In this respect, it regulates pivotal cell surface events, including trans‐membrane signaling, and… Expand
Flow-cytometric monitoring of disease-associated expression of 9-O-acetylated sialoglycoproteins in combination with known CD antigens, as an index for MRD in children with acute lymphoblastic…
- S. Chowdhury, Suman Bandyopadhyay, C. Mandal, Sarmila Chandra, C. Mandal
- Medicine
- BMC Cancer
- 1 February 2008
BackgroundOver expression of 9-O-acetylated sialoglycoproteins (Neu5,9Ac2-GPs, abbreviated as OAcSGP) has been demonstrated as a disease-associated antigen on the lymphoblasts of childhood acute… Expand