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Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade
Findings suggest that p38MAPK in leukemic cells promotes WA-induced apoptosis, and therefore WA holds promise as a new, alternative, inexpensive chemotherapeutic agent for the treatment of patients with leukemia of both lymphoid and myeloid origin.
Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38…
- Susmita Mondal, C. Mandal, R. Sangwan, S. Chandra, C. Mandal
- Biology, ChemistryMolecular Cancer
- 13 September 2010
The results demonstrate that WithaD enhance the ceramide accumulation by activating N-SMase 2, modulate phosphorylation of the JNK and p38MAPK and induced apoptosis in both myeloid and lymphoid cells along with primary cells derived from leukemia patients.
O‐acetylation of GD3 prevents its apoptotic effect and promotes survival of lymphoblasts in childhood acute lymphoblastic leukaemia
Enhanced levels of 9‐O‐acetylated GD3 (9‐ O‐AcGD3) are observed in the lymphoblasts of patients and leukaemic cell line versus disialoganglioside GD3 in comparison to the normal cells, suggesting that O‐acetYLation of GD3, like that of O‐ acetylated sialoglycoproteins, might be a general strategy adopted byLeukaemic blasts towards survival in ALL.
Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition
9-O-acetylated GD3 triggers programmed cell death in mature erythrocytes.
Disialoganglioside GD3-synthase over expression inhibits survival and angiogenesis of pancreatic cancer cells through cell cycle arrest at S-phase and disruption of integrin-β1-mediated anchorage.
Mahanine drives pancreatic adenocarcinoma cells into endoplasmic reticular stress-mediated apoptosis through modulating sialylation process and Ca2+-signaling
- Sayantani Sarkar Bhattacharya, C. Mandal, R. S. Albiez, S. Samanta, C. Mandal
- BiologyScientific Reports
- 2 March 2018
This study describes a molecular scenario how PDAC cells are driven into apoptosis by mahanine by UPR-driven ER stress-associated and ROS-mediated calcium signaling and possibly defective sialylation.
A Glycomic Approach Towards Identification of Signature Molecules in CD34+ Haematopoietic Stem Cells from Umbilical Cord Blood.
- Suchandra Chowdhury, Kaushik Bhattacharya, C. Mandal
- BiologyAdvances in experimental medicine and biology
Two studies indicate a few signature molecules, forming a unique glycomic template, which may be a potential indicator, reassuring the normal profile of these stem cells, to be used for future transplantation.
High level of sialate-O-acetyltransferase activity in lymphoblasts of childhood acute lymphoblastic leukaemia (ALL): enzyme characterization and correlation with disease status
A newly-developed non-radioactive ELISA can quickly detect sialate-O-acetyltransferase, and thus, may become a suitable tool for ALL-monitoring in larger scale.
Autophagy-independent induction of LC3B through oxidative stress reveals its non-canonical role in anoikis of ovarian cancer cells
- E. M. Satyavarapu, R. Das, C. Mandal, A. Mukhopadhyay, C. Mandal
- Biology, ChemistryCell Death & Disease
- 17 September 2018
Evidence for a non-canonical role of LC3B in promoting anoikis in contrast to autophagy is found and may be considered as a potential therapeutic target molecule in ovarian cancer.