• Publications
  • Influence
Functions and Biosynthesis of O-Acetylated Sialic Acids
TLDR
O-Acetylated sialic acids represent cancer markers, as shown for acute lymphoblastic leukemia, and they are known to play significant roles in the regulation of ganglioside-mediated apoptosis.
Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade
TLDR
Findings suggest that p38MAPK in leukemic cells promotes WA-induced apoptosis, and therefore WA holds promise as a new, alternative, inexpensive chemotherapeutic agent for the treatment of patients with leukemia of both lymphoid and myeloid origin.
Oxidative inhibition of Hsp90 disrupts the super‐chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo
TLDR
Results provide evidence for mahanine‐induced ROS‐mediated destabilization of Hsp 90 chaperone activity resulting in Hsp90‐Cdc37 disruption leading to apoptosis, suggesting its potential as a specific target in pancreatic cancer.
Racemoside A, an anti-leishmanial, water-soluble, natural steroidal saponin, induces programmed cell death in Leishmania donovani.
TLDR
Racemoside A, a water-soluble steroidal saponin purified from the fruits of Asparagus racemosus, is a potent anti-leishmanial molecule effective against antimonial-sensitive and -unresponsive Leishmania donovani promastigotes.
Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38
TLDR
The results demonstrate that WithaD enhance the ceramide accumulation by activating N-SMase 2, modulate phosphorylation of the JNK and p38MAPK and induced apoptosis in both myeloid and lymphoid cells along with primary cells derived from leukemia patients.
Induction of glycosylation in human C-reactive protein under different pathological conditions.
TLDR
It is convincingly demonstrated that human C-reactive protein is glycosylated in some pathological conditions.
Effect of Aloe vera on nitric oxide production by macrophages during inflammation
TLDR
AVL possesses acute and chronic antiinflammatory activity, which is partly mediated by reduced production of NO, which in turn prevents the release of inflammatory mediators.
Aloe vera leaf exudate induces a caspase-independent cell death in Leishmania donovani promastigotes.
TLDR
It has been demonstrated that, in promastigotes of L. donovani (IC(50) = 110 microg ml(-1)), AVL mediates this leishmanicidal effect by triggering a programmed cell death, indicating that although promastIGote death was induced by an apoptotic-like mechanism similar to metazoan apoptosis, the pathways of induction and/or execution differed at the molecular level.
...
1
2
3
4
5
...