Polyphenols: food sources and bioavailability.
- C. Manach, A. Scalbert, C. Morand, C. Rémésy, L. Jiménez
- BiologyAmerican Journal of Clinical Nutrition
- 1 May 2004
The nature and contents of the various polyphenols present in food sources and the influence of agricultural practices and industrial processes are reviewed, and bioavailability appears to differ greatly between the variousPolyphenols, and the most abundantpolyphenols in the authors' diet are not necessarily those that have the best bioavailability profile.
HMDB 4.0: the human metabolome database for 2018
This year's update to the HMDB, HMDB 4.0, represents the most significant upgrade to the database in its history and should greatly enhance its ease of use and its potential applications in nutrition, biochemistry, clinical chemistry, clinical genetics, medicine, and metabolomics science.
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies.
- C. Manach, G. Williamson, C. Morand, A. Scalbert, C. Rémésy
- MedicineAmerican Journal of Clinical Nutrition
Gallic acid and isoflavones are the most well-absorbed polyphenols, followed by catechins, flavanones, and quercetin glucosides, but with different kinetics, and the least well- absorption polyphenol are the proanthocyanidins, the galloylated tea catech ins, andThe anthocyanins.
Dietary Polyphenols and the Prevention of Diseases
- A. Scalbert, C. Manach, C. Morand, C. Rémésy, L. Jiménez
- Medicine, BiologyCritical reviews in food science and nutrition
- 1 June 2005
Experimental studies on animals or cultured human cell lines support a role of polyphenols in the prevention of cardiovascular diseases, cancers, neurodegenerative diseases, diabetes, or osteoporosis, but no clear associations have been found between cancer risk and polyphenol consumption.
Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies.
It is time to rethink the design of in vitro and in vivo studies, so that these issues are carefully considered, and the length of human intervention studies should be increased, to more closely reflect the long-term dietary consumption of polyphenols.
Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice
- C. Manach, C. Morand, Á. Gil-Izquierdo, C. Bouteloup-Demange, C. Rémésy
- MedicineEuropean Journal of Clinical Nutrition
- 1 February 2003
In case of a moderate or high consumption of orange juice, flavanones may represent an important part of the pool of total polyphenols present in plasma.
Phenol-Explorer 3.0: a major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content
- J. Rothwell, J. Pérez‐Jiménez, A. Scalbert
- Computer Science, MedicineDatabase J. Biol. Databases Curation
- 6 October 2013
The third release of the Phenol-Explorer database is reported, which adds data on the effects of food processing on polyphenol contents in foods, and is the first database on the effect of foodprocessing onpolyphenol content and all data may be traced back to original sources.
How should we assess the effects of exposure to dietary polyphenols in vitro?
Human intervention studies have provided clear evidence that dietary polyphenols are at least partly absorbed and that they have the potential to exert biological effects.
Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties
Polyphenols and prevention of cardiovascular diseases
Future intervention studies should include a detailed assessment of the bioavailability of polyphenols, and more studies with purepolyphenols will also be needed to establish their role in the prevention of cardiovascular diseases.