• Publications
  • Influence
Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor.
A G protein-coupled receptor for the pineal hormone melatonin was recently cloned from mammals and designated the Mel1a melatonin receptor. We now report the cloning of a second G protein-coupledExpand
  • 792
  • 50
  • PDF
Cloning and characterization of the rat GALR1 galanin receptor from Rin14B insulinoma cells.
Galanin is a ubiquitous neuropeptide that regulates a wide array of physiological processes via interaction with specific G protein-coupled receptors. A rat galanin receptor cDNA was cloned from theExpand
  • 219
  • 15
Cloning of a melatonin‐related receptor from human pituitary
We have cloned an orphan G protein‐coupled receptor from a human pituitary cDNA library using a probe generated by PCR. The cDNA, designated H9, encodes a protein of 613 amino acids that is 45%Expand
  • 147
  • 14
  • PDF
Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
The neuropeptide galanin mediates a diverse spectrum of biological activities by interacting with specific G protein-coupled receptors. We have used homology genomic library screening and polymeraseExpand
  • 81
  • 4
Cloning and characterization of the rat 5‐HT5B receptor
A gene encoding a novel G protein‐coupled 5‐hydroxytryptamine (5‐HT) receptor, termed 5‐HT5B, was cloned. The ligand binding profile of this receptor is distinct from that of other cloned 5‐HTExpand
  • 72
  • 4
  • PDF
Characterization of human 5-HT1 receptors expressed in Sf9 insect cells.
Four human 5-HT receptor subtypes (5-HT1A, 5-HT1D alpha, 5-HT1D beta and 5-HT1E) have been expressed in Sf9 insect cells. All four human 5-hydroxytryptamine receptors produced by Sf9 cells had theExpand
  • 27
  • 2
A Novel Long-Acting Selective Neuropeptide Y2 Receptor Polyethylene Glycol-Conjugated Peptide Agonist Reduces Food Intake and Body Weight and Improves Glucose Metabolism in Rodents
Selective activation of the neuropeptide Y (NPY)2 receptor to suppress appetite provides a promising approach to obesity management. A selective NPY2 polyethylene glycol-conjugated (PEGylated)Expand
  • 55
  • 2
  • PDF
Age-dependence of effects of A1 adenosine receptor antagonism in rat hippocampal slices.
1. Population excitatory postsynaptic potentials (EPSPs) and population spikes evoked in area CA1 of hippocampal slices from aged Fischer 344 rats were significantly smaller in amplitude thanExpand
  • 45
  • 1
Melatonin Modulates Vascular Smooth Muscle Tone
The molecular cloning of a family of melatonin receptors has created a renewed interest in the diverse actions of the hormone melatonin. The redioligand 2-[125I]iodomelatonin has identified potentialExpand
  • 66
  • 1
Indanyl piperazines as melatonergic MT2 selective agents.
Optimization of a benzyl piperazine pharmacophore produced N-acyl-4-indanyl-piperazines that bind with high affinity to melatonergic MT(2) receptors.Expand
  • 23
  • 1