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Age-Related Decline in Oligodendrogenesis Retards White Matter Repair in Mice
Background and Purpose— Aging is one of the major risk factors for white matter injury in cerebrovascular disease. However, the effects of age on the mechanisms of injury/repair in white matterExpand
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  • Open Access
Blockface histology with optical coherence tomography: A comparison with Nissl staining
tl;dr
Spectral domain optical coherence tomography (SD-OCT) is a high resolution imaging technique that generates excellent contrast based on intrinsic optical properties of the tissue, such as neurons and fibers. Expand
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  • Open Access
Optical coherence tomography visualizes neurons in human entorhinal cortex
Abstract. The cytoarchitecture of the human brain is of great interest in diverse fields: neuroanatomy, neurology, neuroscience, and neuropathology. Traditional histology is a method that has beenExpand
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MRI parcellation of ex vivo medial temporal lobe
tl;dr
We have identified several cytoarchitectonic features in the medial temporal lobe with high resolution ex vivo MRI, including gray matter structures such as the entorhinal layer II 'islands', perirhinallayer II-III columns, presubicular 'clouds', granule cell layer of the dentate gyrus as well as lamina of the hippocampus. Expand
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  • Open Access
Polarization-sensitive optical coherence tomography of the human brain connectome
The human brain is composed of approximately 100 billion neurons that ‘communicate’ through an intricate network of axons and dendrites.1 The difficulty of tracing these 3D neuronal pathways,Expand
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  • Open Access
Holographic laser Doppler ophthalmoscopy.
We report laser Doppler ophthalmoscopic fundus imaging in the rat eye with near-IR heterodyne holography. Sequential sampling of the beat of the reflected radiation against a frequency-shiftedExpand
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  • Open Access
Characterizing the optical properties of human brain tissue with high numerical aperture optical coherence tomography.
tl;dr
We develop a systematic method that includes the confocal parameter for modeling the depth profiles of high NA OCT, when the confocation parameter cannot be ignored. Expand
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Holographic laser Doppler imaging of microvascular blood flow.
We report on local superficial blood flow monitoring in biological tissue from laser Doppler holographic imaging. In time-averaging recording conditions, holography acts as a narrowband bandpassExpand
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  • Open Access
as-PSOCT: Volumetric microscopic imaging of human brain architecture and connectivity
tl;dr
We developed a fully automatic serial sectioning polarization sensitive optical coherence tomography (PSOCT) system to enable volumetric reconstruction of human brain samples with unprecedented sample size and resolution. Expand
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En face speckle reduction in optical coherence microscopy by frequency compounding.
We report the use of frequency compounding to significantly reduce speckle noise in optical coherence microscopy, more specifically on the en face images. This method relies on the fact that theExpand
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