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Nipype: A Flexible, Lightweight and Extensible Neuroimaging Data Processing Framework in Python
We present Nipype (Neuroimaging in Python: Pipelines and Interfaces), an open-source, community-developed, software package, and scriptable library. Expand
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Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI
The Functional Activities Questionnaire (FAQ) and Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) are frequently used indices of cognitive decline in Alzheimer's disease (AD). TheExpand
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Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects.
Although beta-amyloid (Abeta) plaques are a primary diagnostic criterion for Alzheimer's disease, this pathology is commonly observed in the brains of non-demented older individuals. To explore theExpand
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Relationships between β-amyloid and functional connectivity in different components of the default mode network in aging.
Although beta-amyloid (Aβ) deposition is a characteristic feature of Alzheimer's disease (AD), this pathology is commonly found in elderly normal controls (NC). The pattern of Aβ deposition asExpand
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Comparing predictors of conversion and decline in mild cognitive impairment
Objective: A variety of measurements have been individually linked to decline in mild cognitive impairment (MCI), but the identification of optimal markers for predicting disease progression remainsExpand
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Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer's disease.
The factors driving clinical heterogeneity in Alzheimer's disease are not well understood. This study assessed the relationship between amyloid deposition, glucose metabolism and clinical phenotypeExpand
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Associations between Alzheimer disease biomarkers, neurodegeneration, and cognition in cognitively normal older people.
IMPORTANCE Criteria for preclinical Alzheimer disease (AD) propose β-amyloid (Aβ) plaques to initiate neurodegeneration within AD-affected regions. However, some cognitively normal older individualsExpand
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Alzheimer's Disease Neurodegenerative Biomarkers Are Associated with Decreased Cognitive Function but Not β-Amyloid in Cognitively Normal Older Individuals
β-Amyloid (Aβ) plaque deposition and neurodegeneration within temporoparietal and hippocampal regions may indicate increased risk of Alzheimer's disease (AD). This study examined relationshipsExpand
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Aβ Deposition in aging is associated with increases in brain activation during successful memory encoding.
To investigate early effects of beta-amyloid (Aβ) on neuronal function, elderly normal controls (NCs, age range 58-97) were scanned with Pittsburgh Compound-B (PIB) positron emission tomography (aExpand
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Neural compensation in older people with brain β-amyloid deposition
Recruitment of extra neural resources may allow people to maintain normal cognition despite amyloid-β (Aβ) plaques. Previous fMRI studies have reported such hyperactivation, but it is unclear whetherExpand
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