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Risk stratification in the long-QT syndrome.
Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes
Recent studies indicate that mammals, including humans, maintain some capacity to renew cardiomyocytes throughout postnatal life. Yet, there is little or no significant cardiac muscle regeneration… Expand
Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease.
- D. Fatkin, C. Macrae, +13 authors B. McDonough
- Biology, Medicine
- The New England journal of medicine
- 2 December 1999
BACKGROUND Inherited mutations cause approximately 35 percent of cases of dilated cardiomyopathy; however, few genes associated with this disease have been identified. Previously, we located a gene… Expand
α-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: A disease of the sarcomere
We demonstrate that missense mutations (Asp175Asn; Glu180Gly) in the alpha-tropomyosin gene cause familial hypertrophic cardiomyopathy (FHC) linked to chromosome 15q2. These findings implicated… Expand
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing
Alternative splicing has a major role in cardiac adaptive responses, as exemplified by the isoform switch of the sarcomeric protein titin, which adjusts ventricular filling. By positional cloning… Expand
Variants conferring risk of atrial fibrillation on chromosome 4q25
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans and is characterized by chaotic electrical activity of the atria. It affects one in ten individuals over the age of… Expand
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
We conducted a genome-wide association study testing single nucleotide polymorphisms (SNPs) and copy number variants (CNVs) for association with early-onset myocardial infarction in 2,967 cases and… Expand
C/EBPβ Controls Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling
The heart has the ability to grow in size in response to exercise, but little is known about the transcriptional mechanisms underlying physiological hypertrophy. Adult cardiomyocytes have also… Expand
Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure.
- R. V. van Kimmenade, J. Januzzi, +8 authors Y. Pinto
- Journal of the American College of Cardiology
- 19 September 2006
OBJECTIVES This study sought to explore the role of new biomarkers in heart failure (HF). BACKGROUND We investigated the utility of novel serum markers alone or together with natriuretic peptide… Expand
Rapid behavior—based identification of neuroactive small molecules in the zebrafish
Neuroactive small molecules are indispensable tools for treating mental illnesses and dissecting nervous system function. However, it has been difficult to discover novel neuroactive drugs. Here, we… Expand