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Spontaneously Hypertensive Rats (SHR) present deficits in prepulse inhibition of startle specifically reverted by clozapine
Deficits in an operational measure of sensorimotor gating - the prepulse inhibition of startle (PPI) - are presented in psychiatric disorders such as schizophrenia, bipolar disorder, and attentionExpand
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Expression profile of neurotransmitter receptor and regulatory genes in the prefrontal cortex of spontaneously hypertensive rats: Relevance to neuropsychiatric disorders
The spontaneously hypertensive rat (SHR) strain was shown to be a useful animal model to study several behavioral, pathophysiological and pharmacological aspects of schizophrenia andExpand
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Peripubertal exposure to environmental enrichment prevents schizophrenia-like behaviors in the SHR strain animal model
Schizophrenia is a highly disabling mental disorder, in which genetics and environmental factors interact culminating in the disease. The treatment of negative symptoms and cognitive deficits withExpand
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Low expression of Gria1 and Grin1 glutamate receptors in the nucleus accumbens of Spontaneously Hypertensive Rats (SHR)
The Spontaneously Hypertensive Rat (SHR) strain is a classical animal model for the study of essential hypertension. Recently, our group suggested that this strain could be a useful animal model forExpand
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Plasma copeptin and metabolic dysfunction in individuals with bipolar disorder
This study aimed to compare plasma copeptin levels, the c‐terminal of provasopressin, between individuals with bipolar disorder (BD) and healthy controls and to assess the relation between copeptinExpand
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The Impact of Environmental Enrichment in Rats Subjected to the Lithium-Pilocarpine Model : Behavioral Assessment and Molecular Changes in the Hippocampus
Epilepsy is a neurological condition characterized by unpredictable recurrent seizures that affects about 50 million people worldwide. In Temporal Lobe Epilepsy (TLE), the most common form ofExpand