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Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives.
In this report we disclose the synthesis, vasodilatory activity, and identification of bioactive conformation of new N-acylhydrazone and N-methyl-N-acylhydrazone derivatives, structurally designed byExpand
Antihypertensive profile of 2-thienyl-3,4-methylenedioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor.
TLDR
The synthesis and antihypertensive profile of LASSBio-1027, a new analogue of the lead compound 3,4-methylenedioxybenzoyl-2-thienylhydrazone, represents a potential strategy for the treatment of arterial hypertension. Expand