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Nucleotide sequence of the structural genes for an anion pump. The plasmid-encoded arsenical resistance operon.
A model is proposed in which these gene products form an anion translocating ATPase for extrusion of arsenite and arsenate from resistant cells. Expand
Modulation of the trans-suppression activity of hepatitis C virus core protein by phosphorylation
HCV core protein is a phospho-protein and in HuH-7 cells, its trans suppression of HBV gene expression and replication is positively regulated by PKA and PKC. Expand
A Plant Gene Encoding a Myb-like Protein That Binds Telomeric GGTTTAG Repeats in Vitro *
The data suggest that the minimum length of a telomeric DNA for AtTRP1 binding consists of five GGTTTAG repeats and that the optimal AtTRp1 binding may require eight or more GGTT TAG repeats. Expand
Cloning, expression, and purification of human cyclophilin in Escherichia coli and assessment of the catalytic role of cysteines by site-directed mutagenesis.
Results rule out the recently proposed mechanism involving the formation of tetrahedral hemithioorthoamide involved in catalysis and immunosuppressant binding, which involves distortion of bound substrate with a twisted peptidyl-prolyl amide bond. Expand
Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor
In vitro selection of viral variants with decreased sensitivity to a C2-symmetric protease inhibitor results in a substantial decrease in the inhibitory activity of the drug on the enzyme and a comparable increase in viral resistance. Expand
Arsenate reductase of Staphylococcus aureus plasmid pI258.
Arsenate reductase encoded by Staphylococcus aureus arsenic-resistance plasmid pI258 was overproduced in Escherichia coli and purified. The purified enzyme reduced radioactive arsenate to arseniteExpand
Human and Escherichia coli cyclophilins: sensitivity to inhibition by the immunosuppressant cyclosporin A correlates with a specific tryptophan residue.
The human T-cell protein cyclophilin shows high affinity for and is the proposed target of the major immunosuppressant drug cyclosporin A (CsA). Cyclophilin also has peptidyl prolyl cis-transExpand
The role of the WSXWS equivalent motif in growth hormone receptor function.
It is shown that Y222A and S226A receptors have structural perturbations, which result in decreased signal transduction, and the crystal structure of the ligand-occupied extracellular domain of growth hormone receptor indicates that Tyr222 and Ser226 have important interactions within the second beta-barrel domain, providing a structural basis for results. Expand
A new compound, withangulatin A, promotes type II DNA topoisomerase-mediated DNA damage.
Withangulatin A, a new compound with a known chemical structure and from the antitumor Chinese herb Physalis angulata L, was found to act on topoisomerase II to induce topoisomerase II-mediated DNAExpand
Nuclear translocation and anchorage of the growth hormone receptor.
The rat nuclear GH receptor and BP are characterized based on their distinct antigenic identity and it is shown that the full-length receptor is associated with the nucleus, including the respective subnuclear fractions (nucleoplasm, outernuclear membranes, inner nuclear membranes, and chromatin). Expand