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Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?
Animal models that mimic fetal androgen excess may provide unique insight into the origins of the PCOS syndrome, and the prenatally androgenized female rhesus monkey shows particular relevance to PCOS. Expand
Insulin resistance and impaired insulin secretion in prenatally androgenized male rhesus monkeys.
PA males do not exhibit elevated androgens during adulthood, suggesting that insulin resistance and impaired pancreatic beta-cell function may result from fetal reprogramming of key metabolic tissues. Expand
Sex hormones, insulin sensitivity, and diabetes mellitus.
This brief review surveys present knowledge of the sex differences in body composition, insulin sensitivity, and risk for development of type 2 diabetes mellitus derived from studies in humans and nonhuman primates. Expand
The surgical management of Graves' disease.
The indications for surgical management of Graves' disease are discussed with emphasis on available data supporting the extent of thyroid resection based on the incidences of hypothyroidism, recurrence of hyperthyroidism , recurrent laryngeal nerve injury and hypoparathyroidism. Expand
Prenatal androgen excess negatively impacts body fat distribution in a nonhuman primate model of polycystic ovary syndrome
The relationship between the timing of prenatal androgen exposure and body composition phenotypes in this nonhuman primate model for PCOS may provide insight into the heterogeneity of metabolic defects found in PCOS women. Expand
Hemoglobinopathy case finding by pulse oximetry
This case reiterates the limitations of pulse oximetry in patients with dyshemoglobinemias, while introducing its use as a case‐finding tool for such conditions. Expand
Pioglitazone improves insulin action and normalizes menstrual cycles in a majority of prenatally androgenized female rhesus monkeys.
Whether pioglitazone will improve menstrual cyclicity in a fetal programming model for polycystic ovary syndrome and insulin resistance plays a mechanistic role in maintaining anovulation in a majority of PA female monkeys is investigated. Expand
Rhabdomyolysis and diabetes: a mitochondrial connection.