• Publications
  • Influence
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate GeneticsExpand
  • 500
  • 52
  • PDF
From Kratom to mitragynine and its derivatives: Physiological and behavioural effects related to use, abuse, and addiction
Kratom (or Ketum) is a psychoactive plant preparation used in Southeast Asia. It is derived from the plant Mitragyna speciosa Korth. Kratom as well as its main alkaloid, mitragynine, currentlyExpand
  • 163
  • 23
  • PDF
Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs
Major depression is a highly prevalent severe mood disorder that is treated with antidepressants. The molecular targets of antidepressants require definition. We investigated the role of the acidExpand
  • 193
  • 14
  • PDF
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
Significance Alcohol is a widely consumed drug in western societies that can lead to addiction. A small shift in consumption can have dramatic consequences on public health. We performed the largestExpand
  • 136
  • 12
  • PDF
Drugs as instruments: a new framework for non-addictive psychoactive drug use.
Most people who are regular consumers of psychoactive drugs are not drug addicts, nor will they ever become addicts. In neurobiological theories, non-addictive drug consumption is acknowledged onlyExpand
  • 165
  • 10
  • PDF
FGF21 Regulates Sweet and Alcohol Preference.
Fibroblast growth factor 21 (FGF21) is a hormone induced by various metabolic stresses, including ketogenic and high-carbohydrate diets, that regulates energy homeostasis. In humans, SNPs in andExpand
  • 136
  • 10
Serotonin and psychostimulant addiction: Focus on 5-HT1A-receptors
Serotonin(1A)-receptors (5-HT(1A)-Rs) are important components of the 5-HT system in the brain. As somatodendritic autoreceptors they control the activity of 5-HT neurons, and, as postsynapticExpand
  • 236
  • 9
Dissociating effects of cocaine and d-amphetamine on dopamine and serotonin in the perirhinal, entorhinal, and prefrontal cortex of freely moving rats
RationaleNeuroimaging studies with humans showed widespread activation of the cortex in response to psychostimulant drugs. However, the neurochemical nature of these brain activities is notExpand
  • 79
  • 8
Abuse potential and adverse cognitive effects of mitragynine (kratom)
Mitragynine is the major psychoactive alkaloid of the plant kratom/ketum. Kratom is widely used in Southeast Asia as a recreational drug, and increasingly appears as a pure compound or a component ofExpand
  • 52
  • 8
What's conditioned in conditioned place preference?
Conditioned place preference (CPP) is a learned behavior shown in many vertebrates, including humans. CPP occurs when a subject comes to prefer one place more than others because the preferredExpand
  • 177
  • 7