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- Publications
- Influence
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
- Anna Köttgen, E. Albrecht, +222 authors C. Gieger
- Medicine, Biology
- Nature Genetics
- 1 February 2013
Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics… Expand
From Kratom to mitragynine and its derivatives: Physiological and behavioural effects related to use, abuse, and addiction
- Z. Hassan, M. Muzaimi, V. Navaratnam, Nurul H. M. Yusoff, C. Müller
- Medicine
- Neuroscience & Biobehavioral Reviews
- 1 February 2013
Kratom (or Ketum) is a psychoactive plant preparation used in Southeast Asia. It is derived from the plant Mitragyna speciosa Korth. Kratom as well as its main alkaloid, mitragynine, currently… Expand
Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs
- E. Gulbins, M. Palmada, +18 authors J. Kornhuber
- Medicine
- Nature Medicine
- 1 July 2013
Major depression is a highly prevalent severe mood disorder that is treated with antidepressants. The molecular targets of antidepressants require definition. We investigated the role of the acid… Expand
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
- G. Schumann, C. Liu, +124 authors P. Elliott
- Medicine
- Proceedings of the National Academy of Sciences
- 28 November 2016
Significance Alcohol is a widely consumed drug in western societies that can lead to addiction. A small shift in consumption can have dramatic consequences on public health. We performed the largest… Expand
Drugs as instruments: a new framework for non-addictive psychoactive drug use.
- C. Müller, G. Schumann
- Medicine, Psychology
- The Behavioral and brain sciences
- 1 December 2011
Most people who are regular consumers of psychoactive drugs are not drug addicts, nor will they ever become addicts. In neurobiological theories, non-addictive drug consumption is acknowledged only… Expand
FGF21 Regulates Sweet and Alcohol Preference.
- S. Talukdar, B. Owen, +13 authors S. Kliewer
- Biology, Medicine
- Cell metabolism
- 9 February 2016
Fibroblast growth factor 21 (FGF21) is a hormone induced by various metabolic stresses, including ketogenic and high-carbohydrate diets, that regulates energy homeostasis. In humans, SNPs in and… Expand
Serotonin and psychostimulant addiction: Focus on 5-HT1A-receptors
- C. Müller, R. Carey, J. Huston, M. A. D. S. Silva
- Medicine, Biology
- Progress in Neurobiology
- 1 February 2007
Serotonin(1A)-receptors (5-HT(1A)-Rs) are important components of the 5-HT system in the brain. As somatodendritic autoreceptors they control the activity of 5-HT neurons, and, as postsynaptic… Expand
Dissociating effects of cocaine and d-amphetamine on dopamine and serotonin in the perirhinal, entorhinal, and prefrontal cortex of freely moving rats
RationaleNeuroimaging studies with humans showed widespread activation of the cortex in response to psychostimulant drugs. However, the neurochemical nature of these brain activities is not… Expand
Abuse potential and adverse cognitive effects of mitragynine (kratom)
- Nurul H. M. Yusoff, F. W. Suhaimi, +8 authors C. Müller
- Psychology, Medicine
- Addiction biology
- 1 January 2016
Mitragynine is the major psychoactive alkaloid of the plant kratom/ketum. Kratom is widely used in Southeast Asia as a recreational drug, and increasingly appears as a pure compound or a component of… Expand
What's conditioned in conditioned place preference?
- J. Huston, M. A. D. S. Silva, B. Topic, C. Müller
- Medicine, Psychology
- Trends in pharmacological sciences
- 1 March 2013
Conditioned place preference (CPP) is a learned behavior shown in many vertebrates, including humans. CPP occurs when a subject comes to prefer one place more than others because the preferred… Expand