• Publications
  • Influence
A Cellular Mechanism for the Generation of Ventricular Arrhythmias by Acetylstrophanthidin
Transmembrane activity was recorded from canine false tendons bathed with Tyrode's solution at 37°C, resulting in sustained bigeminal rhythms with fixed coupling that may provide a mechanism for various clinically observed arrhythmias induced by cardiac glycosides. Expand
Demonstration of a Dual A‐V Nodal Conduction System in the Isolated Rabbit Heart
The intranodal propagation of atrial and ventricular echoes in in-vitro preparations of the rabbit heart was traced from microelectrode records at many puncture sites, and results completely substantiate previous conclusions based on indirect observations in the dog heart. Expand
Aberrant A‐V Impulse Propagation in the Dog Heart: A Study of Functional Bundle Branch Block
Excessive delay and configurational change of ventricular responses to atrial premature beats, previously attributed to dissociation within the A-V node, were shown to be due to functional block ofExpand
Interaction of Transmembrane Potentials in Canine Purkinje Fibers and at Purkinje Fiber‐Muscle Junctions
Results suggest that the intercellular connections, including those at the junctions, offer relatively low resistance to current flow, and that premature ventricular responses initiated at the tip of the papillary muscle could be blocked at various levels in muscle fibers functionally close to terminal Purkinje fibers or within the Purkinjen system. Expand
Propagation of Impulses across the Purkinje Fiber‐Muscle Junctions in the Dog Heart
The results can be explained satisfactorily by assuming that propagation across the P-M junction is electrical and that the geometry of the functional syncytium changes progressively from a cable-like system at the level of the terminal Purkinje fibers to a two- or three-dimensional irregular syncyTium at the bulk of the myocardial mass. Expand
Electrical Excitability of Atrioventricular Nodal Cells
Responses to single-cell stimulation indicate that summation may be an important feature of propagation within the node, and a cumulative effect of frequency upon excitability (fatigue) was demonstrated. Expand
Influence of cycle length upon refractory period of auricles, ventricles, and A-V node in the dog.
The functional refractory periods of auricular and ventricular muscle, and of the A-V transmission system were estimated in the denervated dog heart and it is postulated that the deviations may represent dissociation of the properties of two different elements in each of these tissues. Expand
A Mechanism for Reentry in Canine Ventricular Tissue
Electrotonic shortening of action potentials of Purkinje fibers at relatively long distances upstream from a site of block facilitated the reentry of proximal elements. Expand
The physiologic basis of reciprocal rhythm.
Some Characteristics of Ventricular Echoes
It was concluded that a self-sustained repetitive circuit may be possible when the round-trip conduction time exceeds the refractory period of the limiting tissue in the node. Expand