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A Double Blind, Placebo-Controlled, Randomized Crossover Study of the Acute Metabolic Effects of Olanzapine in Healthy Volunteers
Background and Rationale Atypical antipsychotics exhibit metabolic side effects including diabetes mellitus and obesity. The adverse events are preceded by acute worsening of oral glucose tolerance… Expand
Assessing screening tests: extensions of McNemar's test.
We address the problem of comparing a new screening test to a currently available screening test in the absence of a gold standard. When both tests are given to each participant in a clinical trial,… Expand
Atypical antipsychotics rapidly and inappropriately switch peripheral fuel utilization to lipids, impairing metabolic flexibility in rodents.
Patients taking atypical antipsychotics are frequented by serious metabolic (eg, hyperglycemia, obesity, and diabetes) and cardiac effects. Surprisingly, chronic treatment also appears to lower free… Expand
Leucine and Protein Metabolism in Obese Zucker Rats
Branched-chain amino acids (BCAAs) are circulating nutrient signals for protein accretion, however, they increase in obesity and elevations appear to be prognostic of diabetes. To understand the… Expand
Impact of chronic alcohol ingestion on cardiac muscle protein expression.
- Rachel L Fogle, C. Lynch, Mary Palopoli, G. Deiter, B. Stanley, T. Vary
- Alcoholism, clinical and experimental research
- 7 May 2010
BACKGROUND Chronic alcohol abuse contributes not only to an increased risk of health-related complications, but also to a premature mortality in adults. Myocardial dysfunction, including the… Expand
Second-generation antipsychotics cause a rapid switch to fat oxidation that is required for survival in C57BL/6J mice.
- C. M. Klingerman, Michelle E. Stipanovic, Mohammad I. Bader, C. Lynch
- Chemistry, Medicine
- Schizophrenia bulletin
- 1 March 2014
Some second-generation antipsychotics (SGAs) increase insulin resistance and fat oxidation, but counter intuitively they do not activate lipolysis. This seems unsustainable for meeting energy… Expand
RNA Sequencing Reveals a Slow to Fast Muscle Fiber Type Transition after Olanzapine Infusion in Rats
Second generation antipsychotics (SGAs), like olanzapine, exhibit acute metabolic side effects leading to metabolic inflexibility, hyperglycemia, adiposity and diabetes. Understanding how SGAs affect… Expand
Control of VWF A2 domain stability and ADAMTS13 access to the scissile bond of full-length VWF.
Rheological shear forces in the blood trigger von Willebrand factor (VWF) unfolding which exposes the Y1605-M1606 scissile bond within the VWF A2 domain for cleavage by ADAMTS13. The VWF A2 domain… Expand
Histocompatibility antigens in progressive systemic sclerosis (PSS; scleroderma)
- C. Lynch, G. Singh, T. Whiteside, G. Rodnan, T. Medsger, B. Rabin
- Journal of Clinical Immunology
- 1 October 1982
Patients with progressive systemic sclerosis (PSS; scleroderma) were typed for the HLA-A, -B, and -DR antigens. No significant differences in the frequencies of any HLA-A or -B antigen were found. In… Expand
N-linked glycan stabilization of the VWF A2 domain.
Shear forces in the blood trigger a conformational transition in the von Willebrand factor (VWF) A2 domain, from its native folded to an unfolded state, in which the cryptic scissile bond… Expand