A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis
Revised diagnostic criteria for neuromyelitis optica
- D. Wingerchuk, V. Lennon, S. Pittock, C. Lucchinetti, B. Weinshenker
- Medicine, PsychologyNeurology
- 23 May 2006
Revised diagnostic criteria for definite neuromyelitis optica (NMO) that require optic neuritis, myelitis, and at least two of three supportive criteria: MRI evidence of a contiguous spinal cord lesion 3 or more segments in length, onset brain MRI nondiagnostic for multiple sclerosis, or NMO-IgG seropositivity.
Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
- C. Lucchinetti, W. Brück, J. Parisi, B. Scheithauer, Moses Rodriguez, H. Lassmann
- Medicine, BiologyAnnals of Neurology
- 1 June 2000
At a given time point of the disease, the patterns of demyelination were heterogeneous between patients, but were homogenous within multiple active lesions from the same patient, suggesting that MS may be a disease with heterogeneous pathogenetic mechanisms.
The spectrum of neuromyelitis optica
Cortical demyelination and diffuse white matter injury in multiple sclerosis.
- A. Kutzelnigg, C. Lucchinetti, H. Lassmann
- Psychology, MedicineBrain : a journal of neurology
- 1 November 2005
Global brain pathology in multiple sclerosis is analysed, focusing on the normal-appearing white matter (NAWM) and the cortex, to suggest that multiple sclerosis starts as a focal inflammatory disease of the CNS, which gives rise to circumscribed demyelinated plaques in the white matter.
The Immunopathology of Multiple Sclerosis: An Overview
Recent evidence is described that the spectrum of MS pathology is much broader, including demyelination in the cortex and deep gray matter nuclei, as well as diffuse injury of the normal‐appearing white matter.
Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients.
The results imply pathogenic roles for specific chemokine-chemokine receptor interactions in MS and suggest new molecular targets for therapeutic intervention.
A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica.
The extent of complement activation, eosinophilic infiltration and vascular fibrosis observed in the Devic NMO cases is more prominent compared with that in prototypic multiple sclerosis, and supports a role for humoral immunity in the pathogenesis of NMO.
Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis
Although lesion size >5 cm was associated with a slightly higher EDSS at last follow-up, long-term prognosis in patients with disease duration >10 years was better compared with a population-based multiple sclerosis cohort matched for disease duration (EDSS 3.5; P < 0.001).