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  • Influence
Sympathetic modulation of immunity: relevance to disease.
Optimal host defense against pathogens requires cross-talk between the nervous and immune systems. This paper reviews sympathetic-immune interaction, one major communication pathway, and itsExpand
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Bidirectional Communication between the Brain and the Immune System: Implications for Physiological Sleep and Disorders with Disrupted Sleep
This review describes mechanisms of immune-to-brain and brain-to-immune signaling involved in mediating physiological sleep and altered sleep with disease. The central nervous system (CNS) modulatesExpand
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Potential use of drugs that target neural-immune pathways in the treatment of rheumatoid arthritis and other autoimmune diseases.
Many autoimmune disorders share two common features, dysregulation of the immune system and stress pathways. Two stress pathways, the hypothalamic-pituitary-adrenal (HPA) axis and the sympatheticExpand
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Dual Role for Noradrenergic Innervation of Lymphoid Tissue and Arthritic Joints in Adjuvant-Induced Arthritis
The role of noradrenergic innervation in the disease outcome of adjuvant-induced arthritis (AA) has been examined following (1) systemic administration of guanethidine and (2) local application ofExpand
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  • Open Access
The importance of timing of adrenergic drug delivery in relation to the induction and onset of adjuvant-induced arthritis
Stressful events often precede onset and exacerbate established rheumatic diseases. There are numerous reports of abnormal autonomic function in rheumatoid arthritis (RA) patients. Targeting theExpand
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Changes in the density and distribution of sympathetic nerves in spleens from Lewis rats with adjuvant‐induced arthritis suggest that an injury and sprouting response occurs
Previously we demonstrated reduced norepinephrine concentrations in spleens from Lewis rats with adjuvant‐induced arthritis (AA), an animal model of rheumatoid arthritis. This study extends theseExpand
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Proinflammatory cytokines and sickness behavior in rheumatic diseases.
This review describes mechanisms of immune-to-brain signaling that may contribute to disease-related changes in mood, affect and behavior in chronic inflammatory rheumatic diseases. The centralExpand
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Differences in the injury/sprouting response of splenic noradrenergic nerves in Lewis rats with adjuvant-induced arthritis compared with rats treated with 6-hydroxydopamine
Sympathetic nerves in the spleen undergo an injury and sprouting response with development of adjuvant-induced arthritis (AA), a model of rheumatoid arthritis (RA). The objective of the present studyExpand
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Age-Related Changes in Noradrenergic Sympathetic Innervation of the Rat Spleen Is Strain Dependent
Previous findings from our laboratory revealed an age-related decline in noradrenergic (NA) sympathetic innervation of the spleen in male Fischer 344 (F344) rats. The purpose of this study was toExpand
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  • Open Access