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Dantrolene Inhibition of Ryanodine Receptor Ca2+Release Channels
The results indicate that both the RYR1 and the RYP3, but not the Ryr2, may be targets for dantrolene inhibitionin vivo. Expand
Dantrolene Inhibition of Sarcoplasmic Reticulum Ca2+Release by Direct and Specific Action at Skeletal Muscle Ryanodine Receptors*
Evidence is provided of a high-affinity, monophasic inhibition by dantrolene of ryanodine receptor Ca2+ channel function in isolated sarcoplasmic reticulum vesicles prepared from malignant hyperthermia-susceptible and normal pig skeletal muscle and a mechanism of action is suggested in which danterolene may act directly at the skeletal muscle ryanODine receptor complex to limit its activation by calmodulin and Ca2+. Expand
Identification of the Calmodulin Binding Domain of Connexin 43*
These results provide the first direct evidence that CaM binds to a specific region of the ubiquitous gap junction protein Cx43 in a Ca2+-dependent manner, providing a molecular basis for the well characterized Ca2-dependent inhibition of Cx 43-containing gap junctions. Expand
Malignant hyperthermia: excitation-contraction coupling, Ca2+ release channel, and cell Ca2+ regulation defects.
This review focuses on the biochemical and physiological alterations in the skeletal muscle of MH-susceptible pigs and humans that appear responsible for this inherited disorder and the possiblity of a defect in Ca2+ regulation in tissues other than skeletal muscle. Expand
Cellulose digestion by domestic turkeys fed low or high fiber diets.
Preconditioning to an HF diet does appear to improve cellulolysis in turkeys, and this appears to improve fibrolysis in birds fed either a high (16.13%, HF) or low (2.80%, LF) fiber diet. Expand
Phosphorylation of Nodulin 26 on Serine 262 Affects Its Voltage-sensitive Channel Activity in Planar Lipid Bilayers (*)
Results suggest that phosphorylation of serine 262 of nodulin 26 modulates channel activity by conferring voltage sensitivity. Expand
Calmodulin and protein kinase C regulate gap junctional coupling in lens epithelial cells.
  • M. Lurtz, C. Louis
  • Biology, Medicine
  • American journal of physiology. Cell physiology
  • 1 December 2003
CaM- mediated inhibition of lens gap junctions is associated with sustained, micromolar Cai2+ concentrations, whereas PKC-mediated inhibition of Lens gap junications is associatedwith agonist activation of second messenger pathways that are independent of changes in Cai 2+. Expand
Mechanisms of Pi regulation of the skeletal muscle SR Ca2+ release channel
Inorganic phosphate (Pi) accumulates in the fibers of actively working muscle where it acts at various sites to modulate contraction. To characterize the role of Pi as a regulator of the sarcoplasm...
Abnormal ryanodine receptor channels in malignant hyperthermia.
It is proposed that a defect in a low-affinity Ca2+ binding site is responsible for the altered gating of MHS SR channels, providing a testable hypothesis for the molecular basis of this inherited disorder. Expand
Tissue distribution of ryanodine receptor isoforms and alleles determined by reverse transcription polymerase chain reaction.
The results thus demonstrate expression of two ryr isoforms in each type of striated muscle, and all ryrisoforms in a number of regions of the nervous system, and the wide distribution of ryr1 in the brain provides a possible neurogenic etiology of malignant hyperthermia. Expand