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Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein.
TLDR
It is demonstrated that ADRP mRNA is expressed in a variety of tissues and cultured cell lines and localizes to neutral lipid storage droplets in cultured murine 3T3-L1 adipocytes, murine MA-10 Leydig cells, Chinese hamster ovary (CHO) fibroblasts, and human HepG2 hepatoma cells. Expand
Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets.
TLDR
Investigation of the lipid fraction of rat epididymal adipocytes suggests that perilipin plays a role in the specialized lipid storage function of adipocytes, and Immunocytochemical studies with specific antiserum shows that the perilipIn is closely associated with the periphery of lipid storage droplets in cultured adipocytes. Expand
A highly sensitive adenylate cyclase assay.
TLDR
The high sensitivity of this method permits detection of the small amounts of cyclic AMP formed at low enzyme concentrations or at early time points in kinetic studies. Expand
Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity
TLDR
The data reveal a major role for perilipin in adipose lipid metabolism and suggest perilipIn as a potential target for attacking problems associated with obesity. Expand
Functional Conservation for Lipid Storage Droplet Association among Perilipin, ADRP, and TIP47 (PAT)-related Proteins in Mammals,Drosophila, and Dictyostelium *
TLDR
It is shown that GFP-tagged TIP47 co-localizes with isolated intracellular lipid droplets and that related proteins from species as diverse as Drosophila and Dictyostelium can also target mammalian or Drosophile lipid droplet surfaces in vivo, strongly indicating that they have a common function for lipid deposition and/or mobilization. Expand
Perilipin A Increases Triacylglycerol Storage by Decreasing the Rate of Triacylglycerol Hydrolysis*
TLDR
It is concluded that perilipin A increases the triacylglycerol content of cells by forming a barrier that reduces the access of soluble lipases to stored lipids, thus inhibiting triacyLglycersol hydrolysis. Expand
Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells.
TLDR
The properties, distribution, localization, and potential functions of perilipins and ADRP, as well as those of vimentin and the recently-described 'capsular' proteins, in lipid storage and metabolism are discussed. Expand
LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues.
TLDR
A detailed sequence analysis of all murine PAT proteins reveals that LSDP5, TIP47 and ADFP share the highest order of sequence similarity, whereas perilipin and S3-12 have more divergent carboxyl- and amino-termini, respectively. Expand
Unique Regulation of Adipose Triglyceride Lipase (ATGL) by Perilipin 5, a Lipid Droplet-associated Protein*
TLDR
These studies establish perilipin 5 as a novel ATGL partner and provide evidence that the protein composition of perilipins at the LD surface regulates lipolytic activity of ATGL. Expand
Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation
TLDR
It is shown that HSL is basally associated with lipid droplet surfaces at a low level in perilipin nulls, but that stimulated translocation from the cytosol to lipid droplets is absent in adipocytes derived from embryonic fibroblasts of perilip in-null mice. Expand
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