C. Lok

Publications232
h-index49
Citations8,384
Highly Influential Citations198
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Patency rates of the arteriovenous fistula for hemodialysis: a systematic review and meta-analysis.
TLDR
In recent years, AVFs had a high rate of primary failure and low to moderate primary and secondary patency rates and consideration of these outcomes is required when choosing a patient's preferred access type.
Risk equation determining unsuccessful cannulation events and failure to maturation in arteriovenous fistulas (REDUCE FTM I).
TLDR
A preoperative, clinical prediction rule to determine fistulas that are likely to fail maturation was created and rigorously validated and applied to predictive risk categories, which predicted risk of FTM to be 24, 34, 50, and 69% and are dependent on age, coronary artery disease, peripheral vascular disease, and race.
Fistula first initiative: advantages and pitfalls.
  • C. Lok
  • Medicine
    Clinical journal of the American Society of…
  • 1 September 2007
TLDR
In an effort to improve VA outcomes, the National Kidney Foundation published the Kidney Disease Outcomes Quality Initiative (K/DOQI) Clinical Practice Guidelines for Vascular Access in 1997, and in the following year, Centers for Medicare and Medicaid Services developed ESRD clinical performance measures (CPM) based on the K/DOZI VA guidelines, in response to the Balanced Budget Act of 1997.
Prevention of dialysis catheter malfunction with recombinant tissue plasminogen activator.
TLDR
The use of rt-PA instead of heparin once weekly, as compared with the use of heParin three times a week, as a locking solution for central venous catheters significantly reduced the incidence of catheter malfunction and bacteremia.
Effect of calcium-based versus non-calcium-based phosphate binders on mortality in patients with chronic kidney disease: an updated systematic review and meta-analysis
TLDR
Analysis of the 11 randomised trials that reported an outcome of mortality showed that patients assigned to non-calcium-based binders had a 22% reduction in all-cause mortality compared with those assigned to calcium-based phosphate binders.
Dialysis initiation, modality choice, access, and prescription: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.
TLDR
The need to move away from a "one-size-fits-all" approach to dialysis and provide more individualized care that incorporates patient goals and preferences while still maintaining best practices for quality and safety is represented during the KDIGO conference.
Hemodialysis infection prevention with polysporin ointment.
TLDR
The prophylactic application of topical Polysporin Triple antibiotic ointment to the central venous catheter insertion site reduced the rate of infections and was associated with improved survival in hemodialysis patients.
KDOQI Clinical Practice Guideline for Vascular Access: 2019 Update.
TLDR
The 2019 update to the KDOQI Clinical Practice Guideline for Vascular Access is a comprehensive document intended to assist multidisciplinary practitioners care for chronic kidney disease patients and their vascular access.
Arteriovenous fistula outcomes in the era of the elderly dialysis population.
TLDR
Age should not be a limiting factor when determining candidacy for AVF creation due to equivalent survival and procedural rates, and failure of fistula maturation is a primary concern to patients of all ages.
Increased hemodialysis catheter use in Canada and associated mortality risk: data from the Canadian Organ Replacement Registry 2001-2004.
TLDR
There has been a decrease in fistulae and grafts with a subsequent increase in catheters that is not explained by changes in patient characteristics, and urgent measures are needed to develop strategies to decrease catheter use.
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