• Publications
  • Influence
The phenotype of a germline mutation in PIGA: the gene somatically mutated in paroxysmal nocturnal hemoglobinuria.
Phosphatidylinositol glycan class A (PIGA) is involved in the first step of glycosylphosphatidylinositol (GPI) biosynthesis. Many proteins, including CD55 and CD59, are anchored to the cell by GPI.Expand
  • 123
  • 11
MicroRNA Expression Profiling of Oligodendrocyte Differentiation from Human Embryonic Stem Cells
Background Cells of the oligodendrocyte (OL) lineage play a vital role in the production and maintenance of myelin, a multilamellar membrane which allows for saltatory conduction along axons. TheseExpand
  • 93
  • 7
  • PDF
Molecular structure, dynamic expression, and promoter analysis of zebrafish (Danio rerio) myf‐5 gene
Summary: We isolated a 1,438 bp cDNA fragment that encoded Myf‐5 myogenic factor of zebrafish. The deduced amino acid contained 237 residues, including the basic helix‐loop‐helix domain that isExpand
  • 78
  • 5
  • PDF
HMGA1 Reprograms Somatic Cells into Pluripotent Stem Cells by Inducing Stem Cell Transcriptional Networks
Background Although recent studies have identified genes expressed in human embryonic stem cells (hESCs) that induce pluripotency, the molecular underpinnings of normal stem cell function remainExpand
  • 65
  • 4
  • PDF
Direct Reprogramming of Human Primordial Germ Cells into Induced Pluripotent Stem Cells: Efficient Generation of Genetically Engineered Germ Cells.
Primordial germ cells (PGCs) share many properties with embryonic stem cells (ESCs) and innately express several key pluripotency-controlling factors, including OCT4, NANOG, and LIN28. Therefore,Expand
  • 14
  • 1
Identification of a locus (DSP2) for disseminated superficial porokeratosis at chromosome 12q21.2–24.21
Porokeratosis is a rare disorder of epidermal keratinization that is characterized by the presence of a border called the cornoid lamella. Disseminated superficial porokeratosis (DSP) is a subtype ofExpand
  • 7
  • 1
Differential Sensitivity to JAK Inhibitory Drugs by Isogenic Human Erythroblasts and Hematopoietic Progenitors Generated from Patient‐Specific Induced Pluripotent Stem Cells
Disease‐specific induced pluripotent stem cells (iPSCs) provide an unprecedented opportunity to establish novel disease models and accelerate drug development using distinct tissue target cellsExpand
  • 28
Generation of Glycosylphosphatidylinositol Anchor Protein‐Deficient Blood Cells From Human Induced Pluripotent Stem Cells
PIG‐A is an X‐linked gene required for the biosynthesis of glycosylphosphatidylinositol (GPI) anchors; thus, PIG‐A mutant cells have a deficiency or absence of all GPI‐anchored proteins (GPI‐APs).Expand
  • 16
  • PDF
Bone morphogenetic protein 4 mediates human embryonic germ cell derivation.
Human primordial germ cells (PGCs) have proven to be a source of pluripotent stem cells called embryonic germ cells (EGCs). Unlike embryonic stem cells, virtually little is known regarding theExpand
  • 37
Efficient derivation and genetic modifications of human pluripotent stem cells on engineered human feeder cell lines.
Derivation of pluripotent stem cells (iPSCs) induced from somatic cell types and the subsequent genetic modifications of disease-specific or patient-specific iPSCs are crucial steps in theirExpand
  • 29
  • PDF