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Lipid solubility of vasodilatory vanilloid-type β-blockers on the functional and binding activities of β-adrenoceptor subtypes
Abstract Various vanilloid-type β-adrenoceptor blockers were studied on guinea pig right atrium and trachea and rat colon. In addition, we also investigated their β1-, β2-, and β3-adrenoceptorExpand
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  • 1
[Pharmacological studies on bimolane (AT-1727), a new antineoplastic agent (author's transl)].
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[Antineoplastic action of triptolide and its effect on the immunologic functions in mice (author's transl)].
Triptolide, isolated from Tripterygium hypoglaucum, 0.2 and 0.25 mg/kg injected ip markedly prolonged the survival time of L615-bearing mice, and some mice survived more than a month. The longExpand
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[Characteristics of the cytostatic effects of oridonin in vitro].
  • X. Li, C. Lin, P. Y. Li
  • Biology, Medicine
  • Zhongguo yao li xue bao = Acta pharmacologica…
  • 19 February 1986
The cytostatic effects of oridonin on the MGc80-3 human gastric adenocarcinoma cells in different proliferation stages were studied by colony-forming assay. An exposure of exponential-phase cells toExpand
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[Effects of l-stepholidine on isolated rabbit basilar artery, mesenteric artery, and thoracic aorta].
l-Stepholidine (SPD) has been shown to be effective in treating migraine, but its mechanism is not clear. So the effects of SPD on isolated rabbit basilar artery (BA), mesenteric artery (MA) andExpand
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[Comparative study on the sensitivities of seven human cancer cell lines to rubescensine A].
Rubescensine A (Rub A) was shown to be active against murine tumours in vivo. In the present study, a comparative observation was carried out in 7 lines of human cancer cells, which were exposed inExpand
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[Effects of oridonin on DNA, RNA and protein syntheses of leukemia L 1210 cells studied by autoradiography].
The incorporation of [3H]TdR into DNA of L 1210 cells was inhibited by oridonin in vivo. The labelling index and the mean grain count decreased by 56 and 55%, respectively. The incorporation ofExpand
  • 7
[Absorption, distribution and excretion of [3H]rubescensine A in mice].
Rubescensine A was isolated from Rabdosia rubescens Hemsl. [3H]rubescensine A was injected ip 3.03 mg (1 mCi)/kg to mice. The drug was rapidly taken up by various organs. The highest radioactivitiesExpand
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Xanthine‐analog, KMUP‐2, enhances cyclic GMP and K+ channel activities in rabbit aorta and corpus cavernosum with associated penile erection
The pharmacological properties of KMUP‐2 were examined in isolated rabbit aorta and corpus cavernosum smooth muscle (CCSM). KMUP‐2 caused relaxations that were attenuated by removed endothelium, highExpand
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[Comparison of in vitro assays for the cytotoxic effect of anticancer drugs].
The cytotoxic effects of three anticancer drugs, methotrexate (MTX), 5-fluorouracil (5-Fu) and oridonin (Rub A), were investigated using a human gastric adenocarcinoma cell line (MGc80-3) and a humanExpand
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