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Functional studies on the role of the C-terminal domain of mammalian polo-like kinase
Mammalian polo-like kinase (Plk) acts at various stages in early and late mitosis. Plk is phosphorylated and activated in mitosis, and the proper subcellular localization of Plk is essential forExpand
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Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome.
The beneficial effect of the selective estrogen receptor (ER) modulator tamoxifen in the treatment and prevention of breast cancer is assumed to be through its ability to antagonize the stimulatoryExpand
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Dragon ERE Finder version 2: a tool for accurate detection and analysis of estrogen response elements in vertebrate genomes
We present a unique program for identification of estrogen response elements (EREs) in genomic DNA and related analyses and help to identify genes regulated by direct ER binding to their promoters. Expand
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Estrogen receptor signaling during vertebrate development.
Estrogen receptors are expressed and their cognate ligands produced in all vertebrates, indicative of important and conserved functions. Through evolution estrogen has been involved in controllingExpand
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Positive cross-talk between estrogen receptor and NF-kappaB in breast cancer.
Estrogen receptors (ER) and nuclear factor-kappaB (NF-kappaB) are known to play important roles in breast cancer, but these factors are generally thought to repress each other's activity. However, weExpand
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Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor α, in response to deacetylase inhibition by valproic acid and trichostatin A
Valproate (VPA) and trichostatin A (TSA), inhibitors of zinc-dependent deacetylase activity, induce reduction in the levels of mRNA encoding oestrogen receptor-α (ERα), resulting in subsequentExpand
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Estrogen receptor regulation of carbonic anhydrase XII through a distal enhancer in breast cancer.
The expression of carbonic anhydrase XII (CA12), a gene that encodes a zinc metalloenzyme responsible for acidification of the microenvironment of cancer cells, is highly correlated with estrogenExpand
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MacroRNA underdogs in a microRNA world: evolutionary, regulatory, and biomedical significance of mammalian long non-protein-coding RNA.
The central dogma of molecular biology relegates RNAs to the role of "messengers" of genetic information, with proteins as the end products that perform key roles as regulators and effectors ofExpand
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Targeting liver X receptors in cancer therapeutics
Members of the nuclear receptor superfamily of ligand-dependent transcription factors carry out vital cellular functions and are highly druggable therapeutic targets. Liver X receptors (LXRs) areExpand
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CCT Chaperonin Complex Is Required for the Biogenesis of Functional Plk1
ABSTRACT Experiments from several different organisms have demonstrated that polo-like kinases are involved in many aspects of mitosis and cytokinesis. Here, we provide evidence to show that Plk1Expand
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