New derivatives benzothiophene, benzofuran and indole, their process for the preparation and pharmaceutical compositions containing them
- G. D. Nanteuil, C. Lila, T. Verbeuren, A. Rupin
- Chemistry
- 27 April 1998
Compounds of general formula (I): (CF DRAWING IN BOPI) wherein: X represents an oxygen, sulfur or a group NR3 wherein R3 is as defined in the description, Y represents an oxygen atom , sulfur, a NR 3…
Selection of S18326 as a New Potent and Selective Boronic Acid Direct Thrombin Inhibitor
- A. Rupin, P. Mennecier, C. Lila, G. de Nanteuil, T. Verbeuren
- Biology, ChemistryThrombosis and Haemostasis
- 1 October 1997
The results indicate that the size of the thrombin hydrophobic pocket S2 is sufficient to accept larger residues than proline in the P2 position of Ac-D-Phe-X-boroArg derivatives while this is not the case for other important serine-proteases of the fibrinolysis, coagulation and complement pathways.
New tripeptidic thrombin inhibitors. Influence of P2 and P3 residues on activity and selectivity.
- G. de Nanteuil, P. Gloanec, T. Verbeuren
- Biology, ChemistryBioorganic & Medicinal Chemistry
- 1 August 1995
Large Scale Preparation of Protected 4-Aminomethylbenzamidine. Application to the Synthesis of the Thrombin Inhibitor, Melagatran.
- C. Lila, P. Gloanec, G. D. Nanteuil
- Chemistry
- 2 February 1999
Large Scale Preparation of Protected 4-Aminomethylbenzamidine. Application to The Synthesis of the Thrombin Inhibitor, Melagatran
- C. Lila, P. Gloanec, Guillaume DeNanteuil
- Chemistry
- 1 December 1998
Abstract To allow the preparation of melagatran on a multigram scale, we have investigated several approaches for the synthesis of the key intermediate 4-aminomethylbenzamidine. The only industrially…
Heterocyclisations des hydroxy-6 methoxy-2 hexene-2 et heptene-2 oates de methyle.
- V. Faivre, C. Lila, A. Saroli, A. Doutheau
- Chemistry
- 1989
Benzothiophene, benzofuran and indole derivatives, to processes for their preparation and pharmaceutical compositions containing them
- Nanteuil Guillaume De, C. Lila, A. Rupin, T. Verbeuren
- Chemistry
- 13 October 2000
New derivatives of boronic acid, their process for the preparation and pharmaceutical compositions containing them
- Nanteuil Guillaume De, P. Gloanec, S. Simonet
- Chemistry
- 27 February 1996
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