Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
- Mingxun Wang, Jeremy Carver, N. Bandeira
- BiologyNature Biotechnology
- 1 August 2016
In GNPS, crowdsourced curation of freely available community-wide reference MS libraries will underpin improved annotations and data-driven social-networking should facilitate identification of spectra and foster collaborations.
Influenza A (H(1)N(1)) Antiviral and Cytotoxic Agents from Ferula assa-foetida.
- Chia-Lin Lee, L. Chiang, Y. Wu
- ChemistryJournal of Natural Products
- 19 August 2009
Two new sesquiterpene coumarins were isolated from a CHCl(3)-soluble extract of Ferula assa-foetida through bioassay-guided fractionation and showed greater potency against influenza A virus than amantadine and exhibited the best potency against HepG2, Hep3B, and MCF-7 cancer cell lines.
Asperjinone, a nor-neolignan, and terrein, a suppressor of ABCG2-expressing breast cancer cells, from thermophilic Aspergillus terreus.
- Wen-Ying Liao, Chia-Ning Shen, C. Liaw
- Biology, ChemistryJournal of Natural Products
- 23 February 2012
Treatment with terrein significantly suppressed growth of ABCG2-expressing breast cancer cells, and this suppressive effect was achieved by inducing apoptosis via activating the caspase-7 pathway and inhibiting the Akt signaling pathway, which led to a decrease in ABCG 2- expressing cells and a reduction in the side-population phenotype.
Two new protopines argemexicaines A and B and the anti-HIV alkaloid 6-acetonyldihydrochelerythrine from formosan Argemone mexicana.
- Yuh-Chwen Chang, P. Hsieh, Y. Wu
- Chemistry, BiologyPlanta Medica
- 1 February 2003
Two new protopine-type alkaloids were isolated from MeOH extracts of Formosan Argemone mexicana L. (Papaveraceae) and the known benzo[ c]phenanthridine (+/-)-6-acetonyldihydrochelerythrine exhibited significant anti-HIV activity in H9 lymphocytes with EC50 and TI values of 1.77 microg/mL and 14.6, respectively.
New cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona muricata.
These new acetogenins exhibited significant activity in in vitro cytotoxic assays against two human hepatoma cell lines, Hep G(2) and 2,2,15 and showed a high selectivity toward the Hep 2, 2,15 cell line.
Sharing and community curation of mass spectrometry data with GNPS
- Mingxun Wang, Jeremy Carver, N. Bandeira
- Chemistry
- 2016
The potential of the diverse chemistries present in natural products (NP) for biotechnology and medicine remains untapped because NP databases are not searchable with raw data and the NP community…
Historic perspectives on Annonaceous acetogenins from the chemical bench to preclinical trials.
- C. Liaw, Tung‐Ying Wu, F. Chang, Y. Wu
- Chemistry, BiologyPlanta Medica
- 24 June 2010
The purpose of this review is to give an account of recent studies on this class of compounds and their analogues, which will aid not only in clarifying how the Annonaceous acetogenins act but also in establishing principles for the further development of thisclass of compounds.
Cyclooxygenase‐2 facilitates dengue virus replication and serves as a potential target for developing antiviral agents
- Chun‐Kuang Lin, Chin-kai Tseng, Jin-Ching Lee
- Biology, MedicineScientific Reports
- 20 March 2017
The results reveal that COX-2 is an important factor for DENV replication and can serve as a potential target for developing therapeutic agents against DENV infection.
New cytotoxic flavonoids from Thelypteris torresiana.
- A. Lin, F. Chang, Chin‐Chung Wu, C. Liaw, Y. Wu
- Chemistry, BiologyPlanta Medica
- 1 September 2005
During the search for anti-tumor agents from pteridophytes, three new flavonoids were isolated from Thelypteris torresiana using bioactivity-guided fractionation methods and the structures of the new isolates were elucidated by 1D- and 2D-NMR spectral analysis.
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