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Genetic instabilities in human cancers
Whether and how human tumours are genetically unstable has been debated for decades. There is now evidence that most cancers may indeed be genetically unstable, but that the instability exists at twoExpand
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Requirement for p53 and p21 to sustain G2 arrest after DNA damage.
After DNA damage, many cells appear to enter a sustained arrest in the G2 phase of the cell cycle. It is shown here that this arrest could be sustained only when p53 was present in the cell andExpand
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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
The stability of the Wnt pathway transcription factor β-catenin is tightly regulated by the multi-subunit destruction complex. Deregulated Wnt pathway activity has been implicated in many cancers,Expand
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Genetic instability in colorectal cancers
It has long been considered that genetic instability is an integral component of human neoplasia1–3. In a small fraction of tumours, mismatch repair deficiency leads to a microsatellite instabilityExpand
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DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
Inactivation of tumour suppressor genes is central to the development of all common forms of human cancer. This inactivation often results from epigenetic silencing associated with hypermethylationExpand
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Mutations of mitotic checkpoint genes in human cancers
Genetic instability was one of the first characteristics to be postulated to underlie neoplasia. Such genetic instability occurs in two different forms. In a small fraction of colorectal and someExpand
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Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status
Genes of the RAF family encode kinases that are regulated by Ras and mediate cellular responses to growth signals. Activating mutations in one RAF gene, BRAF, have been found in a high proportion ofExpand
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Genes expressed in human tumor endothelium.
To gain a molecular understanding of tumor angiogenesis, we compared gene expression patterns of endothelial cells derived from blood vessels of normal and malignant colorectal tissues. Of over 170Expand
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Disruption of p53 in human cancer cells alters the responses to therapeutic agents.
We have examined the effects of commonly used chemotherapeutic agents on human colon cancer cell lines in which the p53 pathway has been specifically disrupted by targeted homologous recombination.Expand
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Somatic mutations of the mitochondrial genome in human colorectal tumours
Alterations of oxidative phosphorylation in tumour cells were originally believed to have a causative role in cancerous growth. More recently, mitochondria have again received attention with regardsExpand
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