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Protonation controls ASIC1a activity via coordinated movements in multiple domains

This extensive analysis of activity-dependent conformational changes in ASICs sheds new light on the mechanisms by which protonation controls ASIC activity.
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M1 receptor activation is a requirement for arecoline analgesia.

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Coordinated Movements During ASIC1A Activity

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M 1 receptor activation is a requirement for arecoline analgesia (cid:1)

Results indicate that arecoline antinociception is mediated by the activation of central M 1 muscarinic receptors.
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