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Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial.
TLDR
Estrogen plus progestin therapy increased the risk for probable dementia in postmenopausal women aged 65 years or older and did not prevent mild cognitive impairment in these women, supporting the conclusion that the risks of estrogen plus progESTin outweigh the benefits. Expand
Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study
TLDR
The present report presents data from the Women’s Health Initiative Memory Study, which suggests an increased risk of dementia, but not mild cognitive impairment (MCI), in women given conjugated equine estrogens plus medroxyprogesterone acetate. Expand
Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study.
TLDR
Estrogen therapy alone did not reduce dementia or MCI incidence and increased the risk for both end points combined and use of hormone therapy to prevent dementia or cognitive decline in women 65 years of age or older is not recommended. Expand
Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial.
TLDR
To determine whether a ≥10% reduction in body weight induced by diet, with or without exercise, would improve mechanistic and clinical outcomes more than exercise alone, a single-blind, 18-month, randomized clinical trial was conducted. Expand
Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial.
TLDR
Estrogen plus progestin therapy increased the risk for probable dementia in postmenopausal women aged 65 years or older and did not prevent mild cognitive impairment in these women, supporting the conclusion that the risks of estrogen plus progESTin outweigh the benefits. Expand
Effect of postmenopausal hormones on inflammation-sensitive proteins: the Postmenopausal Estrogen/Progestin Interventions (PEPI) Study.
TLDR
The Postmenopausal Estrogen/Progestin Interventions Trial, a randomized, placebo-controlled trial of the effects of 4 hormone preparations on cardiovascular disease risk factors, found postmenopausal hormones rapidly increased the concentration of the inflammation factor C-reactive protein. Expand
Perception of child vulnerability among mothers of former premature infants.
TLDR
Higher PPCV is associated with worse developmental outcome in premature infants at 1-year adjusted age and Maternal anxiety at neonatal discharge predicts later high P PCV, and interventions to prevent or decrease PPCVs should be targeted at parents who are more anxious at hospital discharge. Expand
Designing clinical trials for assessing the effects of cognitive training and physical activity interventions on cognitive outcomes: The Seniors Health and Activity Research Program Pilot (SHARP-P)
TLDR
Good levels of participation, adherence, and retention appear to be achievable for participants through age 85 years, and depending on the choice of outcome measures, the necessary sample sizes to conduct four-year trials appears to be feasible. Expand
Postmenopausal hormone therapy and cognitive outcomes: The Women's Health Initiative Memory Study (WHIMS)
TLDR
This review discusses major findings from the Women's Health Initiative Memory Study (WHIMS), which reported hormone therapy (HT) increased the risk for dementia and global cognitive decline and WHIMS-MRI reported that while CEE+MPA and CEE-Alone were not associated with increased ischemic brain lesion volume relative to placebo; both CEE+. Expand
Influences of alignment and obesity on knee joint loading in osteoarthritic gait.
TLDR
BMI and alignment were associated with different joint loading measures; alignment was more closelyassociated with the asymmetry or imbalance of loads across the medial and lateral knee compartments as reflected by the frontal plane external adduction moment, while BMI was associated with the magnitude of total tibiofemoral force. Expand
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