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Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction
Caloric restriction (CR) extends the life span and health span of a variety of species and slows the progression of age-related hearing loss (AHL), a common age-related disorder associated withExpand
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Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging
Mutations in mitochondrial DNA (mtDNA) accumulate in tissues of mammalian species and have been hypothesized to contribute to aging. We show that mice expressing a proofreading-deficient version ofExpand
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Molecular inflammation: Underpinnings of aging and age-related diseases
Recent scientific studies have advanced the notion of chronic inflammation as a major risk factor underlying aging and age-related diseases. In this review, low-grade, unresolved, molecularExpand
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered theExpand
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A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice
Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to oldExpand
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Oxidative stress and antioxidants in exercise.
Increased aerobic metabolism during exercise is a potential source of oxidative stress. In muscle, mitochondria are one important source of reactive intermediates that include superoxide (O2*-),Expand
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Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis
  • S. Someya, J. Xu, +8 authors T. Prolla
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 17 November 2009
Age-related hearing loss (AHL), known as presbycusis, is a universal feature of mammalian aging and is the most common sensory disorder in the elderly population. The molecular mechanisms underlyingExpand
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Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study.
BACKGROUND Frailty is a common condition in elders and identifies a state of vulnerability for adverse health outcomes. OBJECTIVE Our objective was to provide a biological face validity to theExpand
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Muscle fiber‐specific apoptosis and TNF‐α signaling in sarcopenia are attenuated by life‐long calorie restriction
Increased tumor necrosis factor‐α (TNF‐α) levels have been found with age and are connected to muscle atrophy and cell loss, yet the signaling events that occur in vivo are unknown. CalorieExpand
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Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise
Sarcopenia, loss of muscle mass and function, is a common feature of aging. Oxidative damage and apoptosis are likely underlying factors. Autophagy, a process for the degradation of cellularExpand
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