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Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart.
A full-length cDNA clone encoding a novel LIM-only protein was isolated and sequenced from a human fetal heart cDNA library and no signal could be detected in brain, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, small intestine, colon or peripheral blood leukocyte.
Characterization of the human 36‐kDa carboxyl terminal LIM domain protein (hCLIM1)
- M. Kotaka, S. Ngai, +4 authors M. Waye
- Biology, MedicineJournal of cellular biochemistry
- 1 February 1999
The hCLIM1 probe was used to hybridize with poly(A)+ RNA of various human tissues, and the putative protein is named human 36‐kDa carboxyl terminal LIM domain protein (h CLIM1, nomenclature approved by the HUGO/GDB Nomenclatures Committee).
Characterization of tissue‐specific LIM domain protein (FHL1C) which is an alternatively spliced isoform of a human LIM‐only protein (FHL1)
The Northern blot and RT‐PCR results revealed that FHL1 is widely expressed in human tissues, including skeletal muscle and heart at a high level, albeit as a relatively low abundance transcript in brain, placenta, lung, liver, kidney, pancreas, and testis.
A genome-based resource for molecular cardiovascular medicine: toward a compendium of cardiovascular genes.
These data represent the most extensive compilation of cardiovascular gene expression information to date and represent a first-generation genome-based resource for molecular cardiovascular medicine.
Role of lipid A of endotoxin in the production of tumour necrosis factor.
- D. K. Ha, S. W. Leung, K. Fung, Y. M. Choy, C. Lee
- Biology, MedicineMolecular immunology
- 1 March 1985
It is suggested that lipid A of LPS molecule is important in causing lethality and TNF release in vivo while the polysaccharide portion may be involved in delivering the lipid A moiety to TNF-producing cells.
A catalogue of genes in the cardiovascular system as identified by expressed sequence tags.
- C. Liew, D. Hwang, +4 authors C. Lee
- Medicine, BiologyProceedings of the National Academy of Sciences…
- 25 October 1994
CDNA probes from reverse-transcribed mRNAs of fetal and adult hearts were used to study differential expression of selected clones in cardiac development and catalogued according to their putative structural and cellular functions.
The rise of nuclear and cytosolic Ca2+ can be uncoupledin HeLa cells
The results suggest that the nucleus of the HeLa cell has its own IP3-sensitive Ca2+ store and that theCa2+ signals in the nucleus and cytosol can be uncoupled.
Chromosomal mapping, tissue distribution and cDNA sequence of four-and-a-half LIM domain protein 1 (FHL1).
A human heart cDNA clone encoding a novel LIM-only protein that possesses four repeats of LIM domain and an extra zinc finger is isolated and sequenced and this putative protein is named four-and-a-half LIM domain protein 1 (FHL1).
Concanavalin A induced apoptosis in murine macrophage PU5-1.8 cells through clustering of mitochondria and release of cytochrome c
The results suggest that ConA was delivered to the mitochondria, induced mitochondrial clustering and released cyto c, and was sufficient to elicit apoptosis in PU5-1.8 cells.
Mitochondrial targeting drug lonidamine triggered apoptosis in doxorubicin-resistant HepG2 cells.
A potential use of LND as an anti-cancer drug to bypass drug resistance and to trigger tumour destruction through apoptosis in HepG2 and R-HepG2 cells is suggested.