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cis-Proline-mediated Ser(P)5 Dephosphorylation by the RNA Polymerase II C-terminal Domain Phosphatase Ssu72*
RNA polymerase II coordinates co-transcriptional events by recruiting distinct sets of nuclear factors to specific stages of transcription via changes of phosphorylation patterns along its C-terminalExpand
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Structure and regulatory mechanism of Aquifex aeolicus NtrC4: variability and evolution in bacterial transcriptional regulation.
Genetic changes lead gradually to altered protein function, making deduction of the molecular basis for activity from a sequence difficult. Comparative studies provide insights into the functionalExpand
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Structural Basis of Rev1-mediated Assembly of a Quaternary Vertebrate Translesion Polymerase Complex Consisting of Rev1, Heterodimeric Polymerase (Pol) ζ, and Pol κ*
Background: Translesion synthesis in mammalian cells is achieved by sequential actions of insertion and extension polymerases. Results: We determined the Rev1-Pol ζ-Pol κ complex structure andExpand
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Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis
In most Gram-negative pathogens, the hydrolysis of UDP-2,3-diacylglucosamine to generate lipid X in lipid A biosynthesis is catalysed by the membrane-associated enzyme LpxH. We report the crystalExpand
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Drug design from the cryptic inhibitor envelope
Conformational dynamics plays an important role in enzyme catalysis, allosteric regulation of protein functions and assembly of macromolecular complexes. Despite these well-established roles, suchExpand
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The molecular mechanism of DHHC protein acyltransferases.
Protein S-acylation is a reversible lipidic posttranslational modification where a fatty acid chain is covalently linked to cysteine residues by a thioester linkage. A family of integral membraneExpand
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Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design.
LpxC is an essential enzyme in the lipid A biosynthetic pathway in gram-negative bacteria. Several promising antimicrobial lead compounds targeting LpxC have been reported, though they typicallyExpand
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Structural basis of the promiscuous inhibitor susceptibility of Escherichia coli LpxC.
The LpxC enzyme in the lipid A biosynthetic pathway is one of the most promising and clinically unexploited antibiotic targets for treatment of multidrug-resistant Gram-negative infections. ProgressExpand
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In vitro reconstitution of Wnt acylation reveals structural determinants of substrate recognition by the acyltransferase human Porcupine
Wnt proteins regulate a large number of processes, including cellular growth, differentiation, and tissue homeostasis, through the highly conserved Wnt signaling pathway in metazoans. PorcupineExpand
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Multi-mode operation of principal component analysis with k-nearest neighbor algorithm to monitor compressors for liquefied natural gas mixed refrigerant processes
Proposed k -nearest neighbor algorithm is employed to classify the operation modes, which is integrated into multi-mode principal component analysis (MPCA) for process monitoring and fault detection. Expand
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